U.S. stock index futures pointed to a lower open on Wall Street on Wednesday, with futures for the S&P 500 down 0.3 percent, Dow Jones down 0.2 percent and Nasdaq 100 down 0.2 percent at 5:15 a.m. EDT.
The euro held near a one-week low against the dollar on Wednesday on concerns over Greece's capacity to resolve its debt crisis after a media report the country wanted to renegotiate a joint EU-International Monetary Fund aid deal.
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European stocks fell 0.2 percent in early trade on Wednesday, led by heavyweight mining and banking shares, halting a two-session rally as renewed concerns over Greece's finances rattled investors.
Asian stocks neared 22-month highs on Wednesday as regional investors largely shrugged off festering worries about fiscal problems in Europe and focused on a recovery in the world economy.
Oil edged 0.3 percent lower on Wednesday after trading near 18-month highs around $87 as a larger-than-expected drop in U.S. gasoline stockps signaled fuel demand was rebounding with an improving economic outlook.
The S&P 500 and Nasdaq rose modestly on Tuesday as the banking sector got a lift from positive analyst comments, while minutes from the Federal Reserve's last meeting eased concern over rising rates.
The Dow Jones industrial average <.DJI> eased 0.03 percent, the Standard & Poor's 500 Index <.SPX> added 0.2 percent and the Nasdaq Composite Index <.IXIC> rose 0.3 percent.
(Reporting by Joanne Frearson, editing by Will Waterman)