“Supernatural” actor Jared Padalecki has some fans worried after he left a fan convention in Rome early. The actor tweeted that he was going home and noted that he needed support from his fans.

Padalecki, 32, not only skipped his scheduled appearance at the Jus In Bello 6 convention in Rome but also canceled a planned appearance at All Hell Breaks Loose 5, a similar event in Melbourne, Australia, next weekend. His manager released a statement that cited exhaustion as Padalecki’s reason for canceling the appearances.

"Jared wanted everyone to know he loves meeting his fans around the world and was very upset at having to cancel his trips to Rome and Australia," the statement said. "Jared has pushed himself to his limits and is suffering from exhaustion. His SPN family is so important to him, and he asks that they Always Keep Fighting. At this time he needs to be home with his family."

“Always Keep Fighting” is the tag line of Padalecki’s recent charity campaign. He is selling T-shirts bearing the slogan through Represent, and the proceeds benefit To Write Love on Her Arms (TWLOHA), a nonprofit that helps those who are dealing with suicide, depression, addiction and self-injury. When the former "Gilmore Girls" star and Texas native started his campaign, he revealed that he'd been dealing with depression for several years. He was diagnosed by a doctor during shooting of “Supernatural” Season 3.

“A doctor came to set and talked to me for about 30 minutes or 45 minutes and said: ‘Jared, I think you’re clinically depressed. I think I should write you a note and we can shut down production for five days and then we can take it from there.’ And it kind of hit me like a sack of bricks,” Padalecki told Variety. “I mean, I was 25 years old. I had my own TV show. I had dogs that I loved and tons of friends and I was getting adoration from fans and I was happy with my work, but I couldn’t figure out what it was; it doesn’t always make sense, is my point. It’s not just people who can’t find a job, or can’t fit in in society, who struggle with depression sometimes.”

Luckily, Padalecki, who plays Sam Winchester on "Supernatural," seems to have a support system in place. Co-star Jensen Ackles remained at the Rome-based convention and assured fans that his on-screen brother needed the break.

“He gives himself a lot to you guys,” Ackles explained. “He gives himself a lot to his family and his friends and his work and his job. And sometimes you just need to get home and rest with your family. … I told him to turn his phone off. I don’t know if he listened to me, but I know how much he loves you all and I know how much it saddens him to not be here right now.”

While Padalecki’s decision to cancel his appearance disappointed many fans, they also seem to understand the Texan’s struggle and have taken to social media to show their support.

Supernatural” audiences shouldn’t worry about the actor too much. He’s currently preparing for Season 11 of the sci-fi/fantasy show. “He's doing better already and is excited about shooting 'Supernatural' Season 11 this July,” the actor's statement read. “For now he's taking a break, but is so appreciative of his fans, and sees and feels their love and support.”

The “Supernatural” Season 10 finale airs Wednesday at 9 p.m. EDT on the CW.