The top after-market Nasdaq gainers Wednesday were Angie's List Inc, J2 Global Inc, Blucora Inc, ValueClick Inc and Zillow Inc while the top after-market Nasdaq losers were Stamps.com Inc, Nanosphere Inc, Tripadvisor Inc and Itron.

Gainers

Angie's List Inc (NASDAQ:ANGI) shares gained 25.48 percent to $17.09 in post-market trading. Angie's List Inc announced that for first quarter of 2013, it expected the revenue to be in the range of $51.0 million to $52.0 million. Analysts’ are expecting the company will report revenue of $50 million for fourth quarter of 2012.

J2 Global Inc (NASDAQ:JCOM) shares climbed 9.61 percent to $34.90 in post-market trading Wednesday. The company Wednesday announced the fourth quarter earnings that exceeded the market expectations. The company posted a profit of $30.2 million, or 65 cents a share, up from $29.8 million, or 62 cents a share, a year earlier versus the analysts’ expectations of earnings of 62 cents on revenue of $92 million.

Blucora Inc (NASDAQ:BCOR) shares advanced 9.46 percent to $16.54 in post-market trading. The stock surged after the company announced strong fourth quarter earnings and full-year results Wednesday. The company said its fourth quarter revenue and adjusted EBITDA grew 46 percent and 19 percent respectively, over the prior year, while the full-year revenue and adjusted EBITDA grew 78 percent and 120 percent respectively, year over year.

The company's board of directors has approved a share repurchase program of up to $50 million of the company's outstanding shares of common stock. Under the program, shares may be repurchased from time to time in the open market for a two-year period.

ValueClick Inc (NASDAQ:VCLK) shares gained 9.21 percent to $23.84 in post-market trading. ValueClick, Inc. announced that for the first quarter of 2013, it expects the revenue to be in the range of $165-$168 million, adjusted EBITDA in the range of $53-$55 million, non-GAAP diluted net income per common share (EPS) $0.39-$0.41 and GAAP diluted net income per common share $0.30-$0.31. According to I/B/E/S Estimates, analysts are expecting the company to report revenue of $165 million, EBITDA of $52 million and EPS of $0.39 for first quarter of 2013.

Zillow Inc (NASDAQ:Z) shares traded 7.01 percent higher at $41.70 in pre-market trading after the company that provides real estate-market information reported the fourth quarter net income of $0.02 per share, down from $0.03 per share last year. The consensus estimate was for break-even results.

Losers

Stamps.com Inc (NASDAQ:STMP) shares declined 24.19 percent to $21.15 in post-market trading. The company announced its fourth quarter results Wednesday and reported revenue of $30.1 million, up 10 percent from a year ago, but below the Street consensus at $31.4 million. Non-GAAP profits were 47 cents a share, ahead of the Street at 44 cents.

Nanosphere Inc (NASDAQ:NSPH) shares dropped 22.73 percent to $2.04 in post-market trading. The company, which is engaged in developing, manufacturing and marketing of molecular diagnostics platform, announced the fourth quarter results and key leadership changes Wednesday. The company reported a 100 percent surge in revenues at $5.1 million in year 2012 from the preceding year and said its customer placements in fourth quarter increased to 56, up 87 percent over 4Q11 while annual placements stood at 166, up 163 percent over 2011.

Tripadvisor Inc (NASDAQ:TRIP) shares slumped 10.45 percent to $42.00 in post-market trading. The company reported earnings that beat analysts’ expectations on a year on year basis, but the revenue decreased 20.37 percent from $212.71 million in the previous quarter. EPS decreased 36.96 percent from $0.46 in the previous quarter.

Itron Inc (NASDAQ:ITRI) shares fell 10.11 percent to $43.01 in post-market trading. The company reported the fourth quarter non-GAAP EPS of $0.58 after the close Wednesday, down from $1.19 in the prior year. The consensus estimate was for EPS of $0.66. The company expects to report the full-year 2013 non-GAAP EPS of $3.00 to $3.25. The consensus estimate is for EPS of $3.66. The stock is now down 4.84 on 17K shares.