The top after-market Nasdaq gainers Wednesday were Apogee Enterprises Inc, Targacept Inc, Questcor Pharmaceuticals Inc, Ancestry.com Inc and Align Technology Inc.

The top after-market Nasdaq losers were Horizon Pharma Inc, Herman Miller Inc, Gevo Inc, Bed Bath & Beyond Inc and Citrix Systems.

Gainers

Apogee Enterprises Inc (APOG) shares climbed 16.23 percent to $20.48 in post-market trading. The shares surged after the company reported a quarterly profit above estimates and raised its full-year profit forecast as sales rose in its architectural business in extended trading Wednesday.

The company said it expected an EPS of 56 and 64 cents for fiscal 2013. Its prior estimate forecast was between 48 and 58 cents per share.

Targacept Inc (TRGT) shares surged 4.22 percent to $27.10 in post-market trading. The company shares have a 52-week trading range of $5.29 - $8.97 and a market capitalization of 642.66 million.

Questcor Pharmaceuticals (QCOR) shares advanced 2.85 percent to $9.30 in post-market trading. The company stock lost 47.84 percent in regular trading Wednesday after the law firm of Wohl & Fruchter LLP announced that it had commenced an investigation into possible violations of federal securities laws by officers and directors of Questcor Pharmaceuticals.

Private health insurer Aetna Inc issued a Clinical Policy Bulletin saying Acthar, lead product of Questcor, was not medically necessary for several conditions for which it had been prescribed and so it would cease coverage of Acthar for those conditions.

Ancestry.com Inc (ACHN) shares rose 3.09 percent to $32.39 in post-market trading. The shares gained after the reports that Discovery Communications Inc. (DISCA)’s TLC was in talks to pick up “Who Do You Think You Are,” a show that works with Ancestry.com to unearth the genealogy of celebrities.

Align Technology Inc (ALGN) shares gained 1.81 percent to $37.70 in post-market trading.  

Losers

Horizon Pharma Inc (HZNP) shares plunged 7.21 percent to $4.25 in post-market trading. The company announced that it intended to offer and sell units in an underwritten public offering, with each unit consisting of one share of its common stock and a warrant to purchase 0.5 of a share of its common stock. All of the units in the offering are being offered by Horizon.  

Herman Miller Inc (MLHR) shares plunged 7.19 percent to $18.85 in post-market trading. The company Wednesday announced fiscal the first quarter profit of $20 million, or 34 cents a share, down from $24.6 million or 42 cents a share, a year earlier.  The company forecast adjusted earnings of 37 cents to 41 cents per share on revenue of $445 million to $465 million against analysts’ expectation of 42 cents and $473 million, revenue per share for the second quarter.

Gevo Inc (GEVO) shares declined 4.55 percent to $3.15 in post-market trading. The company stock lost 1.49 percent in regular trading.

Bed Bath & Beyond Inc (BBBY) shares fell 4.42 percent to $65.75 in post-market trading after it reported the second quarter profit that trailed analysts’ estimates. Profit per share rose to 98 cents from 93 cents a year earlier against the analysts’ expectation of $1.02 a share.

Citrix Systems (CTXS) shares declined 3.48 percent to $78.50 in post-market trading.