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Actor George Clooney speaks onstage at The 100 LIVES initiative, to express gratitude to the individuals and institutions whose heroic actions saved Armenian lives during the Genocide 100 years ago, on March 10, 2015 in New York City. (Neilson Barnard/Getty Images for 100 LIVES)

Twitter was quick to react Wednesday to the news that George Clooney was selling Casamigos, a brand of tequila the actor co-owns, for $1 billion to Diageo Plc. Some users expressed surprise at the development, as most weren't aware of Clooney's forays into the tequila industry.

Casamigos is on track to sell 170,000 12-bottle cases this year, Diageo North America President Deirdre Mahlan said on a call to Bloomberg.

Clooney started the tequila company four years ago with developer Mike Meldman and entertainment entrepreneur Rande Gerber. The sale included an initial consideration of $700 million and an additional $300 million performance-based payout over the next decade, according to a report by Market Watch Wednesday.

The tequila brand has been growing at an increased rate — 40 percent to 50 percent annually — sells for $45 to $55 a pop. Tequila itself is an expanding market and U.S. has seen the liquor sell more than double from 2002 through 2015, according to the Distilled Spirits Council.

This is the drink company Diageo’s biggest acquisition since it bought United Spirits Lte. for $3.2 billion in 2014. The company also owns the vodka company Smirnoff, Scotch Whiskey company Johnnie Walker, the liquor Baileys, and the beer Guinness.

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Other users referenced movies that he was including the critically panned "Batman and Robin" and the acclaimed hit "Oceans 11," among others.

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Another topic broached by Twitter users was Clooney's recently expanded family. He and his wife, Amal, recently had twins, daughter Ella and son Alexander, earlier this month. This personal take on the tequila sale was mentioned by fans that sarcastically said that they were "worried" about how he was going to support his newly expanded family.