With the 2015 U.S. Open just a week away, Novak Djokovic is showing signs of vulnerability as he seeks his third Grand Slam title this year. Shortly after losing to Andy Murray in Montreal, the world’s top tennis player fell to Roger Federer on Sunday in Cincinnati and didn't look particularly sharp. 

Federer defeated Djokovic 7-6(1) 6-3 to win the ATP Western & Southern Open, with Djokovic double-faulting three times in the second set. Djokovic has never won in Cincinnati and seemed to lack confidence against the veteran Federer. It was his second loss in a final in seven days, having been beaten by Murray in Montreal just one week prior. 

Djokovic remains the favorite to win the U.S. Open, but he’s not the favorite that he once was. Before Cincinnati, Djokovic was an odds-on favorite at Bovada.lv to take home the title in Flushing Meadows. With the loss to Federer, Sportsbook.ag lists his betting odds at +110.

Following a brief stint at No.3 in the tennis rankings, Federer regained his place as the world’s No.2 tennis player with his championship on Sunday. It was his third singles title of the year, gaining a measure of revenge from his loss to Djokovic at Wimbledon last month. He has +400 odds to win the U.S. Open title, having been given +600 odds before this past week’s tournament.

Even though Murray lost to Federer in the semifinals at Cincinnati and he’s back to No.3 in the world, he still has the second-best U.S. Open odds at +350. Murray has been eliminated in the quarterfinals of the U.S. Open in each of the last two years after winning the championship in 2012.

Both Federer and Murray have a chance to upset Djokovic in the year’s final Grand Slam, but they won’t get that chance until the tournament’s final match. The world’s No.2 and No.3 players have a good shot to meet in the U.S. Open semifinals.

Federer has gotten the better of Murray in both of their 2015 matches. Before beating the Brit on Saturday, Federer topped Murray in the semifinals of Wimbledon. Federer has won 14 of their 25 career head-to-head matches, including their last five meetings. Their only U.S. Open match came in 2008 when Federer beat Murray in straight sets.

Rafael Nadal hasn’t participated in the U.S. Open in two of the last three years, though he’s had a lot of success in Flushing Meadows. He won the title in 2010 and 2013, while reaching the finals in 2011. But Nadal has only the fifth-best U.S. Open odds after losing in the third round in Cincinnati.

Kei Nishikori has the same U.S. Open odds as Nadal, having beaten him in the quarterfinals at Montreal two weeks ago. Stan Wawrinka, who beat Nadal in their only match this year, has the fourth-best odds.

Below are updated betting odds for the 2015 U.S. Open, courtesy of sportsbook.ag.

Novak Djokovic 110

Andy Murray +350

Roger Federer 400

Stan Wawrinka +1200

Kei Nishikori +1500

Rafael Nadal +1500

Grigor Dimitrov +3000

Marin Cilic +3000

Tomas Berdych +4000

Milos Raonic +4000

Jo-Wilfried Tsonga +5000

Alexander Dolgopolov +10000

Ernests Gulbis +10000

Nick Kyrgios +10000

John Isner +10000

Gael Monfils +10000

David Ferrer +12500

Bernard Tomic +15000

Kevin Anderson +15000

Richard Gasquet +15000

Dominic Thiem +15000