Futures on major U.S. indices point to a lower opening Friday ahead of the U.S. Commerce Dept.'s trade balance report, which details the United States' trade deficit in goods and services.

Futures on the S&P 500 are down 0.69 percent and Nasdaq 100 futures are down 0.54 percent. Futures on the Dow Jones Industrial Average are down 0.60 percent.

Investors are likely to focus on the Commerce Dept.'s trade balance report, which will be released on Friday. The trade deficit, which measures the difference in value between imported and exported goods and services, is expected to narrow to $49.3 billion from $51.8 billion in March.

Market sentiment will also be affected by concerns about Spain's banking woes. Spain's rising borrowing costs are adding considerably to the debt crisis looming over the euro zone.

On Thursday, U.S. markets closed on a mixed note as investor confidence was affected by Fed Chairman Ben Bernanke's lack of a commitment to monetary easing in his congressional testimony on the country's economic outlook. The Dow Jones industrial average rose 0.40 percent, the S&P 500 Index remained flat and the Nasdaq Composite Index declined 0.5 percent.

In a positive note for the job market in the U.S., jobless claims in the week ending June 2 fell to 377,000 from 389,000 in the earlier period.

All major European indices were in the red following concerns among market players about a lack of intervention by European policy makers to solve economic problems in the euro zone. London's FTSE 100 fell by 49.50 points, Germany's DAX 30 Index declined by 64.79 points and France's CAC 40 was down by 49.11 points.

Asian markets fell Friday following negative cues globally, which lowered investor sentiment. Market sentiment could not be revived even though the People's Bank of China cut the benchmark interest rate by 25 basis points on Thursday, the first rate cut of its kind since 2008.