Wigan stunned Premier League Leaders Manchester United with a 1-0 win courtesy of Shaun Maloney's second-half strike at the DW Stadium.
With Manchester City comfortably beating West Brom, this defeat appears to have breathed new life into a seemingly dormant race for the Premier League trophy, with the gap between the two now back to five points.
Manchester United entered the game with an eight point lead over rivals City and it seemed like just a matter of time before they collected a 20th league title. Especially given the identity of their opponents on Wednesday night. Despite some recent good form, Wigan were not expected to provide much opposition having lost every previous meeting with United.
But things did not go to plan during a dramtic night in the Premier League.
Wigan thought they had taken the lead when Victor Moses headed into the back of the net just before the half-hour mark. But the celebrations were halted when it was discovered that the referee had ruled the goal out for a foul on goalkeeper David de Gea by Gary Caldwell.
Given that Wigan were beaten by two Chelsea goals which were offside at the weekend, manager Roberto Martinez's anger at yet another refereeing decision going against his team was understandable.
But Wigan did not let the disappointment get to them and they took a shock lead against the title favorites five minutes into the second half.
Wigan capitalized fully on a two-versus-one situation after a short corner and Shaun Maloney was allowed to cut inside past Phil Jones on the edge of the area before curling a delightful shot past De Gea.
United's struggles were perhaps signified as star-man Wayne Rooney was substituted in the second-half. And despite some inevitable late pressure, the home side hung on for what is a crucial three points for them in their battle to avoid relegation.
But it is the defeat for United that will make the headlines and means that their meeting with City later this month could have plenty of significance after all.