Former Secretary of State Hillary Clinton and Vermont Sen. Bernie Sanders match up yet again in a one-on-one debate Wednesday, as the remaining Democratic candidates face off following primaries in Michigan and Mississippi Tuesday. Hosted by the Washington Post and Univision, the debate will take place at Miami Dade College in Miami, beginning at 8:30 p.m. EST, and will focus on economic and foreign policy.

Clinton maintained a lead over Sanders ahead of Wednesday's debate, despite an upset in which the Vermont senator eked out a victory in a Michigan primary Tuesday with 49.9 percent of voter support, while Clinton won big in Mississippi with 82.6 percent. Support for Clinton among likely Democratic primary voters hovered around 51 percent, giving her nearly a 12-point lead over Sanders at 39.6 percent, according to RealClearPolitics, which takes the average of recent polling data.

Karen Tumulty of the Washington Post, a veteran national political correspondent, will moderate the debate, along with well-known Univision anchors Jorge Ramos and María Elena Salina. The debate will be the first hosted by the Washington Post and by Univision this election season.

While Sunday’s CNN debate between the two candidates in Flint, Michigan, grew heated at several moments, Clinton aimed at the Republican Party when she said, “You know we have our differences, and we get into vigorous debate on issues. But compare the substance of this debate with what you saw on the Republican stage last week.” The Republican debates have frequently veered into personal insults.

Sanders will need to distinguish himself in coming debates as primary voting to pull ahead of Clinton. The Vermont senator will likely continue to challenge the former secretary of state and New York senator on her record with Wall Street while highlighting differences in their economic plans.

sanders clinton Hillary Clinton and Vermont Sen. Bernie Sanders shake hands at the start of their MSNBC debate at the University of New Hampshire in Durham, Feb. 4, 2016. Photo: Getty Images