When and Where: The Barclays Premier League match kicks-off from the DW Stadium at 2.45 p.m. ET. Live coverage of the game will be on the Fox Soccer Channel. You can also watch the match online later in the day with a subscription to FoxSoccer2Go.
Preview: Having grasped an eight-point lead over Manchester City at the top of the Premier League, Manchester United now have a 20th championship firmly in its sight. While the focus has been on City's stumbling form, United have almost quietly gone about amassing 34 points out of the last 36 available.
And the United squad, and perhaps Sir Alex Ferguson in particular, will be desperate to maintain that run and secure the title as quickly as possible, with the dream scenario being that it gets sewn up when the Red Devils travel to their local rivals later this month.
All signs point to Manchester United picking up another three points against Wigan on Wednesday. Incredibly, United have won every previous meeting between the sides, including 13 encounters in the Premier League. What's more, Wigan have conceded 21 goals without reply in the last five matches with their North-West neighbors.
Yet Roberto Martinez's men may feel they have a chance of ending that record this time around. Following two consecutive victories, Wigan were mightily unlucky not to get at least a point from their trip to Chelsea at the weekend.
Both Chelsea goals, and the first blatantly so, were scored from offside positions and so hard done by were Wigan that Martinez received an apology from referees' chief Mike Riley. It is now up to the Wigan players to turn that undoubted frustration into something positive for their next match.
Team News: Wigan's chances of breaking their scoring drought against United will be hampered by the continued absence of Hugo Rodallega, the only member of the current Latics squad to have ever found the net against United.
Mohammed Diame may get a start in midfield after scoring an excellent goal as a substitute against Chelsea.
Nani and Tom Cleverley could both make their returns to the starting lineup on Wednesday as they look for game time following their returns to fitness. With United having played on Sunday, Ferguson could well rotate his side, with Paul Scholes a possibility to be rested. Rafael is fit, despite being taken off against Queens Park Rangers.
Prediction: Wigan has been playing well and should at least make it difficult for the champions-elect at the DW. But United are in a groove and should just have enough to edge this one.
Wigan 0-1 Manchester United