Two-time defending champion and world No. 1 Novak Djokovic faces a potential semifinal clash with long-time rival and No. 3 seeded Roger Federer as Wimbledon announced its draw Friday morning. On the women’s side, No. 1 Serena Williams also seeks to defend her title and equal the all-time mark for most career slams, but her journey could prove difficult in the later stages of the London tournament.

With No. 2 Andy Murray and No. 4 Stan Wawrinka owning the other end of the men's bracket, the top seeded Serb aims for a fifth consecutive slam and could face Federer one round earlier after the titans clashed in the last two Wimbledon finals.

Each resulted in Djokovic victories but went the full five sets, and while Federer’s been plagued by knee and back injuries this year the 34-year-old is still 22-23 all-time against Djokovic.

Sizing up the third leg of a one-year Grand Slam, Djokovic will open the tournament Monday against London-born James Ward and Federer meets Argentina’s Guido Pella in the first round. Djokovic is hoping to be the first player to secure three consecutive Wimbledon crowns since Federer took down five straight between 2003 and 2007.

Murray, who fell to Djokovic at the French Open final and seeks to reclaim Wimbledon after winning in 2013, will face compatriot and tournament wild-card holder Liam Broady. The pair have never squared off but Broady is ranked No. 234 in the world.

Meanwhile, Wawrinka meets 18-year-old American Taylor Fritz, who heads to the All England Club for the first time after falling in the first round of the last three slams.

Japan’s Kei Nishikori earned the No. 5 seed, while Milos Raonic earned the No. 6, followed by Richard Gasquet at No. 7, and Dominic Thiem at No. 8. Croatia’s Marin Cilic is the No. 9 seed, and the Czech Republic’s Tomas Berdych rounds out the top 10 seeds.

On the women's side, Williams, coming off a disappointing letdown at the French final earlier this month, is still awaiting the identity of her first round opponent as the qualification stages wind down but could meet No. 3 seed Agnieszka Radwanska in the semis. But before that potential clash, Williams could avenge her U.S. Open semis loss last year to No. 6 seed Roberta Vinci in the quarters.

No. 2 women’s seed and Williams’ spoiler at the French, Garbine Muguruza of Spain, leads the other side of the bracket and could stare down No. 4 Angelique Kerver in the semis.

Romania’s Simona Halep owns the No. 5 seed, followed by Swiss Belinda Bencic at No. 7, Americans Venus Williams and Madison Keys at No. 8 and No. 9, respectively, and Petra Kvitova of the Czech Republic at No. 10.

The tournament begins Monday and runs until Sunday, July 10. The second round starts on June 29, the third round Friday, July 1, while the fourth round begins on July 4.

The men’s quarterfinals then take place on July 6, the semifinals on July 8, and the final on July 10. The women’s side being the quarters on July 5, the semis on July 7, and the final will be held on July 9.