Democratic vice presidential hopeful Kamala Harris on Wednesday called Donald Trump's Covid-19 response a historic failure that disqualified him from a second term, in a pointed but mostly civil debate with Mike Pence who sought to portray her as extreme.

With Trump's weekend hospitalization for Covid-19 throwing a new importance on the role of the vice president, Pence and Harris spoke separated by plexiglass as a safety precaution 27 days before the election.

Vice President Mike Pence and Kamala Harris's showdown has taken on an unusually pressing quality given President Donald Trump's coronavirus diagnosis, with the White House deputy just a heartbeat away from the presidency
Vice President Mike Pence and Kamala Harris's showdown has taken on an unusually pressing quality given President Donald Trump's coronavirus diagnosis, with the White House deputy just a heartbeat away from the presidency AFP / MANDEL NGAN

Harris, who would be the highest-ranking woman in US history if she enters the White House under a president Joe Biden, immediately attacked Trump's record on Covid-19, which has killed more than 210,000 people in the United States, more than in any other country.

"The American people have witnessed what is the greatest failure of any presidential administration in the history of our country," said Harris, a US senator from California and former prosecutor.

"And frankly, this administration has forfeited their right to reelection based on this," Harris said before a masked and limited audience at the University of Utah.

US Vice President Mike Pence and Democrat Kamala Harris will be separated by a plexiglass barrier when they sit down for their vice presidential debate in Salt Lake City, Utah
US Vice President Mike Pence and Democrat Kamala Harris will be separated by a plexiglass barrier when they sit down for their vice presidential debate in Salt Lake City, Utah AFP / Eric BARADAT

Saying Trump treated front-line health personnel as "sacrificial workers," Harris -- pointing to Trump's own statements to journalist Bob Woodward -- accused the White House of not moving quickly despite knowing the risks of Covid-19.

"The president said it was a hoax. They minimized the seriousness of it," Harris said.

Key dates in the lives of US Vice President Mike Pence and Democratic Party vice presidential Kamala Harris.
Key dates in the lives of US Vice President Mike Pence and Democratic Party vice presidential Kamala Harris. AFP / Kun TIAN

After a raucous debate eight days ago between Trump and Biden, Pence and Harris took a more civil tone with no name-calling, but sharply disagreed on the reaction to the pandemic.

"I want the American people to know, from the very first day, President Donald Trump has put the health of America first," Pence said, pointing to his ban on travel from China on January 31, a month after cases first emerged in Wuhan.

People stroll around the University of Utah campus in Salt Lake City on October 7, 2020, where police officers are watching the scene before the start of the vice-presidential debate between Mike Pence and Kamala Harris
People stroll around the University of Utah campus in Salt Lake City on October 7, 2020, where police officers are watching the scene before the start of the vice-presidential debate between Mike Pence and Kamala Harris AFPTV / Sébastien VUAGNAT

Referencing a controversy that tanked Biden's first presidential campaign in 1988, Pence said the Democrats' Covid plan sounds "a little bit like plagiarism, which is something Joe Biden knows a little bit about."

In contrast to Trump's firehose-like blasts on Biden and his family, Pence demonstrated calm and stability and congratulated Harris on the historic nature of her candidacy.

Harris, the daughter of Jamaican and Indian immigrants, would also be both the first African-American and Asian-American vice president.

SOUNDBITESenator Kamala Harris brands the response to the Covid-19 pandemic under Donald Trump as the "greatest failure" of any US administration, as the debate between her and Vice President Mike Pence opens.
SOUNDBITESenator Kamala Harris brands the response to the Covid-19 pandemic under Donald Trump as the "greatest failure" of any US administration, as the debate between her and Vice President Mike Pence opens. US POOL

But Pence tried to portray her as a radical, saying that Harris -- generally considered close to the Democratic establishment -- was further to the left than socialist Bernie Sanders.

"More taxes, more regulation, banning fracking, abolishing fossil fuel, crushing American energy, economic surrender to China is a prescription for American decline," Pence said, reciting a list Biden would be unlikely to describe as his platform.

Pence, questioned by moderator Susan Page of USA Today, acknowledged that "the climate is changing" but insisted that market solutions were the best way to reduce carbon emissions.

US Vice President Mike Pence during the vice presidential debate
US Vice President Mike Pence during the vice presidential debate AFP / Eric BARADAT

Even if they delved more into substance, the two candidates revealed little new about their policies and were notably evasive on hot-button issues such as abortion and the Supreme Court.

In one moment that went without commentary on stage but triggered an avalanche of social media commentary, a fly found its way onto Pence, spending a visibly long time on his white hair.

The Biden campaign quickly started selling fly-swatters online with the inscription, "Truth over flies."

The two candidates still scoffed at each other's remarks. At one point Harris, firmly but with a smile, reproached Pence, telling him: "Mr vice president, I'm speaking."

They had one of their most intense clashes about racial justice after nationwide protests over police treatment of African-Americans.

Biden "believes that law enforcement has an implicit bias against minorities," Pence said.

"It's a great insult to the men and women who serve in law enforcement. And I want everyone to know who puts on the uniform of law enforcement every day, President Trump and I stand with you," he said.

Pence, criticizing media coverage, insisted that Trump condemned white supremacy despite what some viewers interpreted at the president's shout-out to the far-right Proud Boys group at his debate last week.

Harris pointed to a slew of previous statements by Trump including his notorious remarks that "fine people" were at a 2017 neo-Nazi rally in Charlottesville, Virginia that turned violent.

"I will not sit here and be lectured by the vice president on what it means to enforce the laws of our country," Harris said.

"I'm the only one on this stage who has personally prosecuted everything from child sexual assault to homicide."

Two more presidential debates are scheduled, but they are now up in the air with Trump's diagnosis.

But Trump, ever the hyperbolic showman, said in a Wednesday video that he felt "perfect" and called his infection "a blessing from God."

Trump appeared to be watching the vice presidential debate avidly, tweeting without using Harris' name that "she is a gaffe machine."