Kamala Harris made history Wednesday when she accepted the Democratic nomination for vice president, while joining Barack Obama and Hillary Clinton to condemn President Donald Trump's profound "failure" as a leader.

Harris, the first black woman on a major party's White House ticket, accused Trump of turning "our tragedies into political weapons." And she urged Americans to vote for Joe Biden, "a president who will bring all of us together."

Former president Barack Obama is the keynote speaker on Day 3 of the Democratic National Convention
Former president Barack Obama is the keynote speaker on Day 3 of the Democratic National Convention POOL / Alyssa Pointer

"Donald Trump's failure of leadership has cost lives and livelihoods," the former California prosecutor charged in her acceptance speech.

"We're at an inflection point."

Biden, who faces Trump on November 3, is due to give his own acceptance speech on Thursday, closing a Democratic convention held wholly online and on television due to coronavirus safety precautions.

Senator Kamala Harris
Senator Kamala Harris is Democratic presidential candidate Joe Biden's running mate GETTY IMAGES / Drew Angerer

Shortly before Harris spoke, America's first black president, Barack Obama, delivered his own condemnation of Trump -- and appeal for Biden's election.

Obama said that on handing over the White House to Trump in 2017, he thought the Republican "might show some interest in taking the job seriously; that he might come to feel the weight of the office and discover some reverence for the democracy that had been placed in his care."

Former vice president Joe Biden was formally nominated to be the Democratic presidential candidate
Former vice president Joe Biden was formally nominated to be the Democratic presidential candidate DEMOCRATIC NATIONAL CONVENTION / -

"But he never did," Obama said.

As a result, Trump has left America's "worst impulses unleashed, our proud reputation around the world badly diminished, and our democratic institutions threatened like never before," Obama said.

Trump responded by telling reporters that Obama had been "a terrible president."

Former president Bill Clinton addressing the Democratic convention
Former president Bill Clinton addressing the Democratic convention DEMOCRATIC NATIONAL CONVENTION / -
President Donald Trump
President Donald Trump is seen here delivering a speech at the White House. GETTY IMAGES/Sandy Huffaker

Former first lady and secretary of state Hillary Clinton, who narrowly lost the 2016 presidential election to Trump, pleaded with voters to take nothing for granted in another tight contest.

"This can't be another woulda-coulda-shoulda election," she said.

Others on the night's program included Massachusetts Senator Elizabeth Warren, who unsuccessfully challenged Biden for the nomination, and Nancy Pelosi, speaker of the House of Representatives.

"I know that if we entrust this nation to Joe, he will do for your family what he did for ours: bring us together and make us whole," says former US second lady Jill Biden as she addresses the Democratic National Convention after her husband was formally
"I know that if we entrust this nation to Joe, he will do for your family what he did for ours: bring us together and make us whole," says former US second lady Jill Biden as she addresses the Democratic National Convention after her husband was formally nominated by his party for the presidential election. DC POOL

Former Arizona congresswoman Gabrielle Giffords, who has become a gun control advocate after being shot and severely wounded in a 2011 assassination attempt, also spoke, along with Emma Gonzalez, a survivor of the Parkland school shooting.

Young activists addressed the dangers of climate change and Hispanic immigrants made highly emotional critiques of Trump's policies that they said had torn apart their families.

Much focus was on Obama, who remains a giant force in the Democratic establishment.

Although he took a back seat during the Democratic primaries, he is now campaigning hard for Biden.

"Tonight, I am asking you to believe in Joe and Kamala's ability to lead this country out of dark times and build it back better," he said in his speech.

Obama spoke two days after his wife, Michelle Obama, opened the convention with a scathing takedown of Trump as "the wrong president for our country."

"He cannot meet this moment," she said.

Tuesday's lineup featured two other former presidents -- 95-year-old Jimmy Carter and Bill Clinton, 74, who called the Trump White House "a storm center."

Biden, 77, the former Delaware senator who served as Obama's vice president for eight years, was officially nominated on Tuesday.

Harris, the California senator whom Biden picked to be his vice president, will speak live from Wilmington, Delaware, Biden's hometown and campaign headquarters.

The nomination is the latest in a lifetime of firsts for the 55-year-old daughter of a Jamaican father and Indian mother who were immigrants to the United States.

Harris was the first black attorney general of California, the first woman to hold the post, and the first woman of South Asian heritage to be elected to the US Senate.

Trump has chosen the White House South Lawn as the location for his acceptance speech -- a controversial decision given that presidents are legally required to separate their campaigning from taxpayer-funded governing.