The new installment of “Grey’s Anatomy” will knock you out – literally. In the first released trailer for Season 12 of the hit ABC drama, fans watch as Maggie (Kelly McCreary) unexpectedly throws a punch at woman in red during the premiere episode.

Although the beaten character, named Bethany (Jenny Cooper), is unknown, it was revealed in a promo photo for the upcoming episode that the she’ll tie into the medical storyline of episode 1. The premiere plot will center around the doctors of Grey Sloan Memorial Hospital “springing into action to save the lives of two young girls whose powerful story will force some of the doctors to revisit the effects of bullying on their own pasts,” the synopsis states.

We’ve theorized that Cooper’s character plays the mother of one of the hospitalized girls – the one who is the bully. And while her daughter is being medically treated, we predict that she says a cruel remark to Maggie... one that triggers the doctor (perhaps a former victim of bullying) to strike the woman.

But Maggie won’t be the only one swinging away in the premiere episode, rightfully titled “Sledgehammer.” It was also revealed in the Season 12 trailer that Amelia (Caterina Scorsone) will get a serious arm workout in episode 1 as she uses a sledgehammer to take down a wall.

“What the hell are you doing?” Meredith (Ellen Pompeo) asks her sister-in-law and new roommate as she makes a hole in their shared home.

In the new installment, Mer will be bunking up with Amelia and Maggie in her mother’s home after she decides to leave her McMansion. And you can bet the trio will manage to find themselves in hilarious predicaments – like Amelia partaking in a noisy renovation.

"Right now it's very funny. Those three women are very different and don't have very much in common, which is fantastic," Shonda Rhimes, creator of “Grey’s Anatomy,” told the Hollywood Reporter in August. "Meredith needs support right now and she is related to them so it's not the same as when she was living with Izzie (Katherine Heigl) and George (T.R. Knight) and liked them. She doesn't necessarily need to like them to love them and be in a house with them. It's a fascinating dynamic — it's family."

“Grey’s Anatomy” Season 12 will premiere on Thursday, Sept. 24, at 8 p.m. EDT on ABC.