Lakers Kobe Bryant poured in 39 points and doled out seven assists for the Lakers but lost for the first time in seven games.
Lakers forward Lamar Odom hyper-extended his right knee during the second quarter of the loss and did not return.
The Lakers lost another player, and then a game, ending their brief stay atop the other 29 teams in the league. After the third quarter, they pretty much weren't going to let me get a shot off, Bryant said. Shots didn't go for us.
David West and Chris Paul combine for 72 points in New Orleans Hornets Hornets' victory.
Paul showed with 32 points, 15 assists, three steals and no turnovers in 44 minutes. Tyson Chandler added 12 points and eight rebounds, and Rasual Butler had 10 points and six rebounds for the Hornets, who shot only 5-of-14 from 3-point range.
David West scored 15 of his 40 points in the final period to outscore Los Angeles by himself, and New Orleans beat Los Angeles, 116-105, to snap the Lakers' 15-game home winning streak at Staples Center.
The Hornets finally did in the fourth quarter, and it proved decisive.