Both countries want to strengthen economic ties in peaceful nuclear energy among other areas such as renewable energies or reducing carbon emissions, the official UAE news agency WAM said after Lee's arrival.
The UAE is expected to award the contract estimated to be worth $40 billion to build several nuclear reactors possibly early next week, industry sources said.
A South Korean consortium of Korea Electric Power Corp. (KEPCO) <015760.KS>, Hyundai Engineering and Construction <000720.KS>, Samsung C&T Corp <000830.KS>, and Doosan Heavy Industries <034020.KS> is in the running to win the largest-ever energy deal of the Middle East.
Other bidders include a consortium of General Electric Co and Westinghouse Electric, a subsidiary of Toshiba Corp <6502.T>, and a French consortium led by EDF and GDF Suez and including Areva and oil group Total.
Lee is scheduled to hold a summit meeting with UAE President Sheikh Khalifa bin Zayed al-Nahayan during his two-day visit, the South Korean presidential Blue House said in a statement.
It remains unclear whether South Korea will win the final contract to build nuclear power plants and President Lee's visit to the UAE is part of summit diplomacy to win the final ticket in the bidding, Lee's office said.
The French consortium was initially seen as a front-runner for the deal but it recently appeared to be losing ground to the Korean.
On the Korea Exchange earlier this week, shares of Korea Power Engineering <052690.KS> and Doosan Heavy Industries <034020.KS> rallied on expectations for the deal, analysts said.
IBK Securities analyst Yoon Jin-il said the contract is expected to be split in three stages with the initial order to be worth about $5 billion, but the first-phase winner is likely to take home the remaining two.
Work is expected to begin in 2012, UAE state news agency WAM has said. The UAE is the world's third-largest oil exporter, but it is planning to build a number of nuclear reactors to meet an expected need for an additional 40,000 megawatts of power.
South Korea's commerce and energy ministry said on Monday that it would focus on the nuclear power sector in 2010 and step up work on a plan to develop nuclear reactors with indigenous technology, as it outlined next year's policy objectives.
(Reporting by Cho Mee-young and Jack Kim in Seoul and Ulf Laessing in Dubai and Amena Bakr in Abu Dhabi; editing by Andrew Roche)