An agent is in trouble on “Marvel’s Agents of S.H.I.E.L.D.” After that mysterious substance infected May, she started to go crazy. The new director decided to handle it by sending her away in a straight jacket. The agents will need to keep her alive if they want to save her in Season 4, episode 3.

“Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness,” the synopsis for the ABC drama reveals. Simmons (Elizabeth Henstridge) and Radcliffe (John Hannah) are capable, but magic is not as easy to figure out as the science they have grown up with. They’ll have to get creative.

Radcliffe will also have to hide his latest project, Aida (Mallory Jansen). The Life-Model Decoy (LMD) was introduced in the premiere, and Fitz (Iain De Caestecker) decided they couldn’t tell Simmons. She has to tell the new director (Jason O’Mara) everything, and Radcliffe isn’t legally allowed to work on a project like this. It’s easier for her not to know, but how long can they keep it a secret?

The new director is keeping Coulson (Clark Gregg) in the dark about May (Ming-Na Wen), so he’ll go on a mission. “Coulson, Mack [Henry Simmons] and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide,” the episode 3 summary teases. It would seem this group is what the episode’s title, “Uprising,” refers to.

It looks like the vigilantes will use a power outage to get their way. In the “Agents of S.H.I.E.L.D.” promo video above, Daisy (Chloe Bennet) and Ghost Rider (Gabriel Luna), who will spend some time with his brother Gabe (Lorenzo Henrie James) in the episode, realize that someone is going to use a blackout to create chaos.

Unfortunately, May’s life is going to hang in the balance for longer than usual. Episode 3 will be delayed a week due to the vice presidential debate. When the episode finally airs, fans will hopefully see May’s fate and learn if the director is actually Jeffrey Mace.

“Marvel’s Agents of S.H.I.E.L.D.” Season 4, episode 3 airs Tuesday, Oct. 11, at 10 p.m. EDT on ABC.