The Arizona Cardinals and Philadelphia Eagles are set to meet in the biggest NFC matchup of the Week 8 schedule. While both enter the game at 5-1, the public appears to be favoring the visiting teams.

After being favored by 2.5 points to start the week, the point spread at most Las Vegas casinos is down to two points. Some sports books have Philadelphia as just 1.5-point underdogs. The over/under opened at 49 points, but fell to 48 points two days before the game.

Arizona has been very good at home since the start of last year, winning nine of 11 games. No team, however, has been better on the road than the Eagles, during that time. The Eagles are 7-3 on the road in their last 10 games away from Philadelphia.

Philadelphia could be without one of their top offensive threats. A knee injury that forced Darren Sproles to leave the game against the New York Giants early has him questionable for Sunday. A bye in Week 7, though, could prevent him from missing any time at all.

Sproles was brought in to back up LeSean McCoy, but he’s been as productive as the team’s top running back. Sproles has totaled 409 rushing and receiving yards, while adding two scores on special teams. McCoy has 496 yards with just one touchdown.

Linebacker Mychal Kendricks is questionable, as well as center Jason Kelce. Kendricks has been out since Week 2, and a hernia has kept Kecle off the field since Week 3.

The Cardinals are relatively healthy. Running back Andre Ellington is battling a foot injury, but he’s acknowledged that he won’t be 100 percent until the offseason. Defensive end Calais Campbell was limited at practice on Thursday, and hasn’t played since Week 5.

Arizona has a lead over the San Francisco 49ers and Seattle Seahawks in the NFC West. Philadelphia trails the Dallas Cowboys by a half-game.