Fall TV is back and NBC is kicking off its lineup with a brand new show called "Blindspot." The thriller, which premieres Monday follows a woman named Jane Doe (Jaimie Alexander) who wakes up in a duffel bag in the middle of Times Square naked and covered in dozens of intricate tattoos.

Check out five things you should know before "Blindspot" episode 1 premieres at 10 p.m. EDT: 

1. Cast

Jamie Alexander stars as the main character Jane Doe, a woman who is discovered naked and covered in tattoos in a duffle bag with the words “Call the FBI” written on it. Jane doesn’t have any memory of who she is or how she got to Times Square. Another key player in the series is FBI agent Kurt Weller, played by Sullivan Stapleton, who realizes he has a strange connection to Jane when he finds his name has been tattooed on her back.

“Blindspot” also stars Audrey Esparza (“Black Box”) as Tasha Zapata, Rob Brown (“Coach Carter”) as Edgar Reed, Marianne Jean-Baptiste (“Without a Trace”) as FBI director Bethany Mayfair, Ukweli Roach ("The Royals") as Dr. Borden and Ashley Johnson (“Growing Pains”) as Patterson, head of the forensic science unit. Throughout the series it will be revealed how each person is connected to Jane.

2. Premiere Episode Synopsis

NBC said the first episode will reveal Jane’s tattoos are a lot more than just random designs. While it’s still a mystery who tattooed Jane, the FBI quickly realizes the marks “are clues to solving crimes.”

3. Jane And FBI Agent Kurt Weller Are Connected

The premiere episode will also reveal Agent Weller’s name has been inked onto Jane’s back, but no one knows why. Weller insists he’s never met Jane, but executive producer Martin Gero previously teased fans will learn how Jane and Weller are connected in the second episode.

"It's something that, once [Weller] realizes what it is, it feels like there can be no other reason," Gero told TV Guide. "It's based on an incident in his past that has, in many ways, defined who he is, every part of who he is."

4. Where The Idea For “Blindspot” Came From

Gero told TV Line he’s always had a fascination with puzzles and treasure hunts, and wanted to create a show based around that. When trying to think of ideas the Canadian producer, who was also behind the series “The LA Complex,” said an image popped into his head of “Times Square emptied out [with] this bag that they think is a bomb [but] a woman emerges from it.” He added: “The tattoos and everything came after. … I['ve] never seen a treasure map on a woman’s body. I think that would do all right.”

5. Sneak Peek Videos

Check out a few trailers and clips from "Blindspot" below:

"Blindspot" premieres on NBC on Monday, Sept. 21 at 10 p.m. EDT.