Denver solidified their hold on the AFC West by completing a sweep of the San Diego Chargers last week with a 30-23 win.
Quarterback Peyton Manning went 25-for-42 for 270 yards, three touchdowns and one interception, but Denver also lost running back Willis McGahee to a season ending knee injury.
The Broncos placed McGahee on injured reserve, and will now rely on rookie Ronnie Hillman as the top running back. Hillman has 188 yards and one touchdown on 49 carries this season.
While Denver tries to work through an injured backfield, the 1-9 Chiefs only bright spot is running back Jamaal Charles.
Charles rushed for 87 yards on 17 carries, but Kansas City lost their seventh straight game to the Cincinnati Bengals 28-6 last week.
The Chiefs have struggled on offense, with their main problem being under center. Brady Quinn and Matt Cassel have been in and out of the lineup with injuries or poor play, and neither could lead the Kansas City offense.
Charles may have trouble against Denver, who is sixth against the rush, only allowing 93.8 yards per game.
The game begins at 1 p.m. EDT and will be shown by CBS, or watch a live stream online by purchasing NFL Sunday Ticket Max.
Betting Odds: Denver is favored by 10.5 points
Over/Under: 44 points
Prediction: While this could be a trap game, Manning has the Broncos humming and they should walk away with a big win a solid hold in the AFC West division title.
Predicted Score: Denver 35, Kansas City 10