There appears to be trouble in paradise for the Charlie's Angels best friends, according to media reports.

Drew Barrymore and Cameron Diaz were both at the Golden Globes CAA after party where the two typically bubbly best friends did not speak to each other, OK! Magazine reports.

Both Cameron and Drew were at the party but neither one spoke to each other! a fellow party told the magazine.

They were on opposite sides of the room the entire night.

Cam and Drew, who became best friends while filming Charlie's Angels in 2000, were once each other's sidekicks, going together to clubs, parties, the beach and other places. But now that Cameron has been seriously dating model Paul Sculfor, she's rarely seen without him.