Day Five of the 2015 French Open features several high-profile second round matchups, including the men’s and women’s No. 1 ranked players taking center stage. 

Beginning at 11 a.m. Eastern Time at the Suzanne-Lenglen Court, top ranked Novak Djokovic continues his quest for the first French title of his career with a second-round matchup against Luxembourg’s Gilles Muller. The Serb, who already claimed the first slam of the year in Australia and owns only two losses this season, handily dispatched Jarkko Nieminen in the first round in straight sets.

Djokovic and the 32-year-old Muller squared off once before, with Djokovic sweeping their Round-of-16 matchup in Australia earlier this year. Though Muller did stage an incredible comeback in the first round against Paolo Lorenzi, losing the first two sets 4-6 4-6 and winning three straight with two tie-breakers to advance.

Also on the Suzanne-Lenglen, No. 1 Serena Williams goes head-to-head with Germany’s Anna-Lena Friedsam, who the two-time French champ’s never faced. Williams made quick work of Andrea Hlavackova in the first round 6-2 6-3, but the second round was where she ran into trouble last year, falling to then-unranked Garbine Muguruza in straight sets.

Over at Philippe-Chatrier Court, defending champion Rafael Nadal takes on fellow Spaniard Nicolas Almagro. Nadal, gunning for a 10th Roland Garros title and fresh off a victory over French wild card Quentin Halys, has defeated Almagro in 12 of their 13 career meetings.

Later, No. 3 Andy Murray meets Joao Sousa, a talented 26-year-old who brushed aside Vasek Pospisil in straight sets in the first round. Murray is looking to improve on his semifinal appearance from a year ago and already made the Aussie finals earlier this season. Murray’s never lost a set to Sousa in their five career matches, most recently beating him in Dubai and Melbourne.

The women’s side at Philippe-Chartrier features a potentially exciting match between Denmark’s No. 5 Caroline Wozniacki and Germany’s Julia Goerges. Wozniacki has gone 4-3 against the 26-year-old Goerges with wins in their last two matches. Goerges last defeated Wozniacki in Dubai in 2012, the last of three straight victories.

The full slate of second round matches and there start times can be found at the French’s official site here.

Start Time: 5:00 a.m. EDT

TV Channel: ESPN2 (5 a.m. - 10 a.m.); Tennis Channel (10 a.m. - 3 p.m.)

Live Online: A live stream is available at Tennis Channel Everywhere here