John C. Reilly is joining Ed Helms in the road-trip comedy Cedar Rapids.

The story, by Phil Johnston, centers on a wholesome and naive small-town Wisconsin man (Helms) who, after his role model dies, must represent his company at a regional insurance conference in Cedar Rapids, Iowa, where his mind is blown by the big-town experience.

Reilly's character also is attending the conference and is a family man who sees the event as a vacation and time to let loose.

Miguel Arteta, director of The Good Girl and the upcoming Youth in Revolt, is directing the Fox Searchlight project.

Reilly, whose most recent major feature appearance was in Step Brothers, next appears in Cirque du Freak: The Vampire's Assistant.