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Updated 1:48 pm EDT: Interfax quotes Ukraine Interior Ministry adviser as saying that more than 300 are dead from the crash of flight MH17, including 23 U.S. citizens. 

Updated 1:39 pm EDT: Reuters reports that Russian airline Aeroflot will no longer fly over Ukraine territory. 

Updated 1:38 pm EDT: A Reuters correspondent saw burning wreckage and bodies on the ground in the village of Grabovo, which is 25 miles from the Russian border. It's an area where pro-Russian rebels have been active and have claimed to have shot down other aircraft. 

A Malaysia Airlines passenger plane was shot down over Ukraine on Thursday killing all 295 people on board, according to reports from the Interfax-Ukraine news agency. A Ukrainian interior ministry official is quoted by the news agency, though these reports are still unconfirmed. 

Flight MH17 was flying from Amsterdam to Kuala Lumpur when it came down near the city of Donetsk, which is a stronghold of pro-Russian rebels. Malaysia Airlines tweeted that it lost contact with the Boeing 777 while it was flying over Ukrainian airspace. 

Reuters quoted Ukrainian official Anton Gerashchenko, who posted to his Facebook page: "A civilian airliner travelling from Amsterdam to Kuala Lumpur has just been shot down by a Buk anti-aircraft system ... 280 passengers and 15 crew have been killed."

Interfax-Ukraine also reported that the plane disappared from radar while it was flying at 10,000 meters (33,000 feet). 

The crash site is about 25 miles from the Russia border, reported Reuters.