Two Premier League titans battle on Wednesday at Stamford Bridge when Chelsea host Manchester United in a League Cup fourth-round match.

Both clubs will rest their stars, but the encounter will likely maintain its typical competitive spirit. The two clubs are coming off a contentious Premier League match over the weekend, with the Red Devils earning the tight victory, 3-2.

Manchester United have dominated Chelsea in their last six matches. The Blues have one draw and five losses in that span in all competitions.

Chelsea will be without John Terry, Fernando Torres and Branislav Ivanovic, due to suspension, as well as Frank Lampard, who remains injured. 

Sir Alex Ferguson is expected to rest Robin van Persie, Wayne Rooney, and Rio Ferdinand for Manchester United, while Phil Jones and Chris Smalling are still sidelined. Shinji Kagawa is also inactive after sustaining a knee injury against Braga.

Chelsea have clinched a spot in the quarter-finals in eight of the last 11 years, while Manchester United have qualified for four in a row.

Probable Lineups

Chelsea:

G: Turnbull
D: Azpillicueta, Cahill, Luiz, Bertrand
M: Romeu, Mikel, Moses, Marin, Mata 
F: Piazon

Manchester United:

G: Lindegaard
D: Vermijl, M Keane, Wooton, Buttner
M: Nani, Powell, Fletcher, Scholes, Anderson
F: Welbeck

Prediction: Though the lineups will be different from the most recent decision between the two clubs, Chelsea should have the advantage with a passionate crowd behind them, who swallowed a bitter pill on Sunday. Roberto Di Matteo appears to have a deeper bench, which is crucial for game like this. Expect a tight battle, with the Blues' midfield doing a better job of ball possession.

Predicted Score: Chelsea over Manchester United, 2-1

Where to watch: The League match kicks-off from Stamford Bridge at 3:45 eastern time. Coverage will be provided by the beIN Sport in the U.S. and Sky Sports 1 in the U.K., with an online stream available at http://www.livesoccertv.com/