Shares of the world's largest hamburger chain fell 2.5 percent in premarket trading as same-restaurant sales in its Asia Pacific, Middle East and Africa same-store sales also fell, posting a 1 percent drop.
The decline in U.S. sales at stores open at least 13 months was McDonald's second straight monthly decline and comes less than a week after rival fast-food chain operator Yum Brands Inc
Same-restaurant sales were up 0.7 percent overall for November, helped by a 2.5 percent rise in Europe, McDonald's said.
Fast-food chains like McDonald's were outperforming other restaurant categories until just recently, when rising unemployment began to take a noticeable bite of sales, particularly at breakfast -- where McDonald's leads the industry.
Despite the monthly same-store sales declines in the United States, McDonald's remains a leader in the fast-food industry it had a pivotal role in pioneering.
McDonald's has been outperforming Wendy's/Arby's Group Inc
But its rivals are stepping up with a broad range of inexpensive fare, including a new $1 double cheeseburger from Burger King, a new 99-cent menu from Dunkin Donuts and a value menu from Yum's Taco Bell that offers items for less than $1.
Elsewhere, grocery prices have been falling, prompting some consumers to eat more meals at home.
McDonald's shares traded at $60.40 in premarket trading on Tuesday, down from Monday's New York Stock Exchange close of $61.93.
(Reporting by Brad Dorfman and Lisa Baertlein, editing by Dave Zimmerman)