When and where: The international exhibition match kicks-off from Estadio Azteca in Mexico City at 8 p.m. ET. Live coverage will be provided by ESPN2, with a live stream available on ESPN3.
Preview: After the euphoria of claiming Olympic gold, Mexico's senior side will be looking to build on the huge momentum surrounding the country's soccer as they take on bitter local rivals the United States at the Azteca.
The country's recent success means there is sure to be a phenomenal atmosphere at the home of Mexican soccer. Having won the Under-17 World Cup last year as well as the Gold Cup-with a 4-2 victory in the final over the U.S.-Mexico is riding the crest of a wave that sees them as one of the leading nations in the world.
While there were some senior names present as Mexico capped a fine tournament by defeating Brazil in the Olympic final, the competition largely again showcased the depth in quality that Mexican soccer now possesses.
Against the U.S., El Tri will welcome some of the country's leading stars back into the international fold. Manchester United striker Javier Hernandez is expected to lead the line, while Andres Guardado and Guillermo Ochoa should also appear.
Every player on show for Mexico will be desperate to avoid being in the team that relinquishes the proud record of never having lost to the U.S. on home soil.
That El Tri have won all but one of the 24 contests played between the two sides in Mexico illustrates the difficulty that the U.S. have had over the years.
"We're all aware of that," said U.S. midfielder Maurice Edu, according to the U.S. Soccer website. "It's part and parcel of this fixture and it's something we get excited for. It's going to be a crazy environment. It's one of the biggest games for us and we use that as our own personal motivation. If we get a win here, it's a big deal for us and that's what we're all looking to do on Wednesday night."
While ending their ignominious record is motivation enough for the U.S. squad traveling to Mexico City, there will also be a desire to prove that they are not being left behind in international soccer terms by their neighbors to the South.
U.S. coach Jurgen Klinsmann has a tough job on his hand if he is to make history, though. His side will be missing a quartet of experienced names in Clint Dempsey, Carlos Bocanegra, Jozy Altidore and Michael Bradley.
D: Torres Nilo, Rodriguez, Moreno, Meza
M: Barrera, Viniegra, Lugo, Zavala, Guardado
D: Johnson, Cameron, Edu, Orozco Fiscal
M: Donovan, Beckerman, Jones, Torres, Beasley
Prediction: Shorn of some valuable experience, the U.S. could struggle playing in the intimidating surroundings of the Azteca. Particularly vulnerable could be a largely untested U.S. defense that may feature regular midfielder Maurice Edu. Riding a high from the country's recent success Mexico should get the victory.
Mexico 3-1 USA