Tom Brady
Tom Brady and the Patriots are the biggest favorites in Week 2. Reuters

With Week One in the books, the 2013 NFL season in officially under way. Week Two is set to begin with an AFC East matchup on Thursday night.

The New England Patriots will host the New York Jets in what’s expected to be the least competitive game of the week. The defending division champs are the only double-digit favorites, giving the Jets 12.5 points. The Jets are heavy underdogs, despite picking up a win in Geno Smith’s first career start.

Rookie E.J. Manuel wasn’t as fortunate in his NFL debut. He and the Buffalo Bills lost to the Patriots on a field goal in the final seconds. When they host the Carolina Panthers on Sunday, they will be just one of three home teams that are not favored.

The Arizona Cardinals and New York Giants are the two other home teams who open up the week as underdogs. Arizona, projected to be one of the worst teams in the NFC, is getting one point from the Detroit Lions. New York actually began the year as a frontrunner to win the NFC East, but they did not look good in their opener. Former Bronco Willis McGahee could face his former team, since the Giants are working out the running back after David Wilson’s two fumbles against the Dallas Cowboys.

The Sunday-night matchup could be the best of 2013. The San Francisco 49ers and Seattle Seahawks have the best odds of representing the conference in the Super Bowl, and they’ll face off for the first time this season in Week Two. With the game at CenturyLink Field, the Seahawks are three-point favorites.

Unlike in Week One, there will be just one Monday-evening game. Following their upset loss to the Tennessee Titans, the Pittsburgh Steelers are seven-point underdogs to the Cincinnati Bengals. It’s the most points that the Bengals have given their division rivals since 1989.

Below are the complete betting lines for all the Week Two games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas.

Thursday

New York Jets (+12.5) at New England Patriots, 44

Sunday

San Diego Chargers (+7) at Philadelphia Eagles, 53

Cleveland Browns (+6.5) at Baltimore Ravens, 43.5

Tennessee Titans (+8.5) at Houston Texans, 44

Miami Dolphins (+3) at Indianapolis Colts, 42.5

Carolina Panthers (-3) at Buffalo Bills, 44.5

St. Louis Rams (+7) at Atlanta Falcons, 47

Washington Redskins (+7.5) at Green Bay Packers, 49.5

Dallas Cowboys (+2.5) at Kansas City Chiefs, 46.5

Minnesota Vikings (+6.5) at Chicago Bears, 41

New Orleans Saints (+3) at Tampa Bay Buccaneers, 47

Detroit Lions (-1) at Arizona Cardinals, 47.5

Jacksonville Jaguars (+6) at Oakland Raiders, 39.5

Denver Broncos (-5) at New York Giants, 55

San Francisco 49ers (+3) at Seattle Seahawks, 44.5

Monday

Pittsburgh Steelers (+7) at Cincinnati, 40.5