There’s an opportunity for underdogs to have a big Week 6. Four teams are favored by at least 10 points, and one home team is getting 9.5 points. Only two games have point spreads of fewer than three points.

Below are picks against the spread for every game in Week 6, as well as updated betting odds at Las Vegas and online sportsbooks. Betting lines and trends are courtesy of OddsShark.

Philadelphia Eagles (+3.5) at Carolina Panthers

When Cam Newton is at his best, Carolina might be the top team in the NFC. The quarterback has returned to playing like he did in 2015 when he won the NFL MVP award. He’ll have success at home against Philadelphia’s 30th ranked pass defense. Carson Wentz could have trouble keeping pace with Newton in what is probably the biggest game of his young career.

Prediction ATS: Carolina

New England Patriots (-9.5) at New York Jets

The Jets don’t often beat the Patriots, but they usually play them tough. New York has lost against the spread just once in their last eight meetings with New England, nearly beating the Patriots at MetLife Stadium a year ago during a dismal 4-12 season. The Jets certainly have a chance to stay within 10 points of this New England defense.

Prediction ATS: New York

Miami Dolphins (+11) at Atlanta Falcons

Jay Cutler is averaging 128 passing yards in his last two games, and the Dolphins haven’t scored more than 19 points yet. This won’t end well on the road against last year’s MVP. Matt Ryan and Atlanta should bounce back from their Week 4 upset, coming off a bye week with a now-healthy Julio Jones. Miami could get run out of Mercedes-Benz Stadium.

Prediction ATS: Atlanta

Matt Ryan Atlanta Falcons The Atlanta Falcons have a good chance to cover the spread in Week 6 after a bye in Week 5. Pictured: Matt Ryan drops back to pass during the second half against the Buffalo Bills at Mercedes-Benz Stadium on Oct. 1, 2017 in Atlanta. Photo: Getty Images

Green Bay Packers (-3) at Minnesota Vikings

There’s some value in taking the Vikings, considering the point spread indicates Green Bay would be a nine-point favorite over Minnesota at home. That betting line wouldn’t make much sense between two divisional rivals that have played mostly competitive games in the last few years. The Vikings are 4-2 against the spread in their last six home games against the Packers and 11-3 against the spread in their last 14 home games overall.

Prediction ATS: Minnesota

San Francisco 49ers (+10) at Washington Redskins

The 49ers have come dangerously close to winning their last four games. Eventually, they’re going to break through and get Kyle Shanahan his first win as a head coach. Maybe it won’t come in Washington, but San Francisco has lost four straight games by three points or fewer.

Prediction ATS: San Francisco

Chicago Bears (+6.5) at Baltimore Ravens

The Bears have covered the spread at home in all three games against playoff contenders. Chicago has been awful on the road, losing two games by a combined 43 points. The team won’t get any better away from Soldier Field when Mitchell Trubisky makes his road debut against a defense that will make him pay for rookie mistakes.

Prediction ATS: Baltimore

Detroit Lions (+5.5) at New Orleans Saints

This betting line should be closer to three points than it is to six. Detroit’s only two losses have come by a total of seven points against playoff contenders. New Orleans might be headed for another 7-9 season. After two strong performances, let’s see what the Saints’ defense can do against Matthew Stafford, who threw for 341 yards in a 15-point win in New Orleans a year ago.

Prediction ATS: Detroit

Cleveland Browns (+10) at Houston Texans

Betting on the Browns, especially on the road, just doesn’t make sense. With a 1-20 overall record in the Hue Jackson era, Cleveland is winless in 10 tries on the road. The Browns haven’t covered the spread in their last five road games, and replacing DeShone Kizer with Kevin Hogan probably won’t make much of a difference. The Texans have scored at least 33 points in each of their last three games.

Prediction ATS: Houston

Tampa Bay Buccaneers (-2) at Arizona Cardinals

The Cardinals are old, and their wins came in overtime against two of the NFL’s worst teams. Tampa Bay would be 3-1 with a win against the defending Super Bowl champions if they had a competent kicker. With 10 days to prepare, the Bucs should be able to win in Arizona.

Prediction ATS: Tampa Bay

Jameis Winston Buccaneers Quarterback Jameis Winston of the Tampa Bay Buccaneers during the pregrame of an NFL football game on Oct. 5, 2017 at Raymond James Stadium in Tampa. Photo: Getty Images

Los Angeles Rams (+2.5) at Jacksonville Jaguars

The Jaguars probably can't keep winning with Blake Bortles throwing for just 165 yards per game for much longer. Jacksonville gives up a league-worst 5.4 yards per carry, and that doesn’t bode well against Todd Gurley and the Rams.

Prediction ATS: Los Angeles

Pittsburgh Steelers (+4.5) at Kansas City Chiefs

Anyone doubting Pittsburgh’s offense might have to eat their words this week. Ben Roethlisberger was a little unlucky with a few of his interceptions in Week 5, and he could bounce back in a big way Sunday. Kansas City won’t remain perfect forever, and their first misstep could come against the team that beat them twice last season, holding them to a combined 30 points.

Prediction ATS: Pittsburgh  

New York Giants (+11.5) at Denver Broncos

With all of the injuries they suffered in Week 5, it’s hard to imagine the winless Giants going into Denver and beating the Broncos. That doesn’t mean they can’t stay within striking distance. New York still has a talented defense, which can have its moments against Trevor Siemian and Denver’s offense. The 1-4 Chargers nearly won in Denver this year, and the Broncos have just two wins by more than 10 points in their last 13 games.

Prediction ATS: New York

Los Angeles Chargers (N/A) at Oakland Raiders

There is no available betting line because of the uncertain status of Derek Carr.

Indianapolis Colts (N/A) at Tennessee Titans

There is no available betting line because of the uncertain status of Marcus Mariota.

Season Record ATS: 30-46-1