Two Union Pacific Railroad freight trains Sunday collided head-on in the Oklahoma Panhandle.

The train crash, which left three crew members missing, occurred two miles east of Goodwell, Okla., when a westbound train with three locomotives and 80 rail cars, collided with an eastbound intermodal train consisting of four locomotives and 108 rail cars, according to several news reports.

Union Pacific Railroad spokeswoman Raquel Espinoza said a two-person crew was aboard each train, and officials are unable to account for two engineers and the conductor of the eastbound train, the reports said.

The conductor of the westbound train, who jumped from the train before the two engines collided, appeared to be uninjured, she added.

He's shaken up about the situation, and we are working to make sure that he receives any care that he needs. We're doing everything we can to find the rest of the crew, Espinoza said.

Reports indicate that the two trains, one of which was hauling resin solution, collided traveling around 68 mph and ignited a fire upon impact. Espinoza said the resin load wasn't on fire and was doused with water as a precaution.

About 50 firefighters from the Goodwell, Guymon and Hooker fire departments were on hand and had fire under control by Sunday night.

Once the fire is out then we will have to wait until the wreckage cools - it's all metal - before emergency personnel can get in there, Oklahoma Highway Patrol trooper, Betsy Randolph, said.

One firefighter was taken to a hospital for treatment of a heat-related injury, after temperatures climbed past 100 degrees in the area, Randolph added.

The cause of the Oklahoma train crash has not yet been determined. Multiple news outlets are reporting that it unclear whether there was radio communication between the two trains or if brakes were applied before the collision.