With the Season 28 premiere of “The Simpsons” kicking off tonight, we look at nine of the best guest appearances happening this year. Famous for its guest stars, in its 26-year run, “The Simpsons” have featured cameos from the likes of Michael Jackson and Lady Gaga to Leonard Nimoy and Dr. Stephen Hawking.

From Patton Oswalt to Taraji P. Henson, the latest season of Fox’s hit show will feature old and new faces that you’re definitely not going to want to miss. Check out nine of the best cameos happening this season:

1. Amy Schumer

The “Trainwreck” star will lend her voice to the premiere episode as Mr. Burns’ mother during flashbacks.

2. Allison Janney

Janney will play a neighbor named Julia who starts up a platonic relationship with Homer, although Marge won’t see it that way. “She’s someone who likes beer and likes Homer and has absolutely no interest in him,” said executive producer Al Jean.

3. Sarah Silverman

The “Treehouse of Horror XXVII” episode will see the return of Sarah Silverman, this time, as the voice of Lisa’s imaginary friend who begins to kill Lisa’s real life friends. 

4. Jackie Mason

The 85-year-old comedian will reprise his role as the dead father of Krusty the Clown, Rabbi Hyman Krustofsky. 

5. Magnus Carlsen

If you’re a fan of chess, you’re definitely going to want to watch this season of “The Simpsons.” World chess champion Magnus Carlsen will play himself in an upcoming episode.

6. Michael Sheen and Lizzy Caplan

In an episode that will actually be a sequel to the Season 4 episode, “Kamp Krusty,” Sheen and Caplan will reprise their roles as Dr. William Masters and Virginia Johnson from the show “Masters of Sex.”

7. Patton Oswalt

Oswalt won’t be playing a character on “The Simpsons,” instead, the actor will voice Bart’s guilt after Bart regrets being mean to Lisa.

8. Jason Alexander

In an episode mocking presidential hopeful Donald Trump and his Trump University, Alexander will guest star as the inventor of for-profit colleges in an episode that features Mr. Burns starting his own university.

9. Taraji P. Henson and Keegan-Michael Kay

In what will be the series’ first hour-long episode, the “Empire” star and the “Key & Peele” star will be featured in hip-hop version of “The Great Gatsby.

Season 28 of “The Simpsons” premieres on Fox at 8 p.m. EDT. The first episode of the new season, “Monty Burns’ Fleeing Circus,” will see the Simpsons begging Mr. Burns to fund the rebuilding of Springfield. Burns will agree but in typical fashion, he will have to get something out of it. Watch as Mr. Burns hosts his own variety show at the Springfield Bowl.

The Simpsons Check out some of the best cameos happening on Season 28 of “The Simpsons” this year which premieres Sunday, Sept. 25. Photo: Fox/The Simpsons