The top after-market Nasdaq gainers Wednesday were Mellanox Technologies Ltd, Complete Select Comfort Corp, Skyworks Solutions Inc, QUALCOMM Incorporated and QLogic Corporation.

The top after-market Nasdaq losers were Diana Containerships Inc, Tudou Holdings Limited, Trius Therapeutics, Nanosphere Inc and Smart Balance Inc.

Gainers

The shares of Mellanox Technologies Ltd (MLNX) rocketed 43.34 percent to $95.15 in after-hours trading. The semiconductor company that produces and supplies interconnect products Wednesday reported strong financial results that beat analysts' expectations for the second quarter of the fiscal year 2012.

The Israel-based company reported revenue of $133.5 million for the first quarter of the fiscal year 2012, recording a 111 percent increase over the same period in last year. The company also reported adjusted EPS of 99 cents against the analysts' expectation of 73.5 cent per share.

Select Comfort Corporation (SCSS) Shares climbed 17.13 percent in the post-market session to close at $25.50. The mattress maker reported Wednesday higher-than-expected quarterly results as higher pricing boosted margins and raised its net profit outlook for the year.

Net sales for the quarter increased 27 percent to a second-quarter record of $205 million, compared to $161 million in the same period a year ago and earnings per diluted share of $0.30, a 50 percent increase versus $0.20 per diluted share in the second quarter of 2011 and better than the consensus estimate of $0.27 a share on revenue of $198.3 million.

Skyworks Solutions (SWKS) shares advanced 8.15 percent to $28.81 in post-market trading. The company's shares rose Wednesday after it reported its third fiscal quarter 2012 results that exceeded market expectations. Its revenues for the quarter stood at $389.0 million versus the consensus estimate of $ 382.2 million. The company reported an EPS of 45 cents against analysts' expectation of 44 cents.

QUALCOMM Incorporated (QCOM) shares gained 5.80 percent and reached $59.30 in after-hours trading. The company reported Wednesday that its third quarter profit rose 17 percent on strong demand for its smartphone technology.

Qualcomm reported a profit of $1.21 billion or 69 cents a share, up from $1.04 billion or 61 cents a share a year earlier and excluding acquisition-related costs, stock-based compensation and other impacts. Per-share earnings rose to 85 cents from 73 cents in-line with market expectations. The revenue jumped 28 percent to $4.63 billion versus the consensus estimate of $4.68 billion.

QLogic Corporation (QLGC) shares surged 4.97 percent to $13.30 in after-hours trading Wednesday.

Losers

Diana Containerships Inc (DCIX) slumped 14.58 percent to $6.15 in the post-market session Wednesday. The company announced that it intended to offer and sell 8,100,000 of its common shares in an underwritten public offering.

The containership operator has granted the underwriters a 30-day option to purchase up to a total of 1,215,000 additional common shares. The net proceeds of the offering are expected to be used by the company for general corporate purposes, including vessel acquisitions and working capital.

Tudou Holdings Limited (TUDO) shares plunged 3.31 percent to $25.65 in the post-market trading. The company shares surged 9 percent in regular trading Wednesday.

Trius Therapeutics Inc (TSRX) shares lost 2.89 percent in after-hours trading to reach $6.05. The company shares have a 52-week low of $4.71, a 52-week high of $9.00 and 240.92 million in market capitalization.

Nanosphere Inc (NSPH) shares dropped 2.30 percent to $2.55 in after-hours trading. The company announced that it intended to offer shares of its common stock in a public offering.

Nanosphere also expects to grant the underwriters a 30-day option to purchase additional shares of common stock to cover overallotments, if any, and plans to use the net proceeds from the offering for general corporate purposes and working capital.

Smart Balance (SMBL) shares declined 2.17 percent to $9.48 in after-hours trading. The company shares have a 52-week low of $9.34, a 52-week high of $10.29 and 571.13 million in market capitalization.