The top after-market Nasdaq gainers Wednesday were Sigma Designs Inc, Sucampo Pharmaceuticals Inc, ADTRAN Inc, Star Scientific Inc, and Ebix Inc., while the top after-market Nasdaq losers were ANADIGICS Inc, E*TRADE Financial Corporation, SS and C Technologies Holdings Inc. and Vera Bradley Inc.

Gainers

Sigma Designs Inc. (NASDAQ:SIGM) shares surged 6.33 percent to $4.70 in post-market trading. The company reported a fourth quarter non-GAAP loss of $0.54 per share after the bell Wednesday, compared to the loss of $0.43 per share a year ago. Net revenues rose to $44.2 million from $35.6 million reported last year. The consensus estimate pegged a loss of $0.25 per share on revenues of $43.43 million.

Sucampo Pharmaceuticals Inc. (NASDAQ:SCMP) shares climbed 5.05 percent to $5.20 in post-market trading Wednesday. The company Wednesday reported fourth-quarter profit of $13.53 million or $0.32 per share, up from $2.70 million or $0.06 per share in the same period last year. Revenues rose to $34.86 million up from $14.22 million last year.

ADTRAN Inc. (NASDAQ:ADTN) shares advanced 3.95 percent to $20.81 in post-market trading. The company shares lost 5.92 percent on regular trading, Wednesday.

Star Scientific Inc. (NASDAQ:STSI) shares gained 3.43 percent to $2.11 in post-market trading. The company stock has a 52-week trading average of $1.56-$5.05 and a market capitalization of $298.42 million.

Ebix Inc. (NASDAQ:EBIX) shares advanced 2.57 percent to $15.94 in post-market trading.  The company stock has a 52-week trading average of $12.08-$24.90 and a market capitalization of $579.34 million.

Losers

ANADIGICS Inc. (NASDAQ:ANAD) shares declined 4.98 percent to $2.10 in post-market trading. The company announced that it is offering to sell shares of its common stock in an underwritten public offering.

E* TRADE Financial Corporation (NASDAQ:ETFC) shares dropped 4.91 percent to $11.24 in post-market trading. The company announced that Citadel Equity Fund Ltd., an affiliate of Citadel LLC, plans to offer 27,394,448 shares of E*TRADE's common stock in an underwritten offering. The closing of the offering is expected to occur on or about Mar. 19, 2013, subject to customary closing conditions.

SS and C Technologies Holdings, Inc. (NASDAQ:SSNC) shares slumped 4.47 percent to $26.50 in post-market trading. The company stock has a 52-week trading average of $20.50 -$28.13 and a market capitalization of $2.19 billion.

Vera Bradley Inc. (NASDAQ:VRA) shares fell 3.66 percent to $23.98 in post-market trading. The company stock has a 52-week average of $18.91-$38.49 and a market capitalization of $1.01 billion.