The 2015 U.S. Open is set to begin on Monday morning in Flushing Meadows, as the final Grand Slam tournament of the year gets underway. Marin Cilic looks to defend his title, and favorite Novak Djokovic begins his quest to win a third Grand Slam in 2015.

The action begins at 11 a.m. ET, but it won’t be televised until 1 p.m. ET. ESPN will have coverage until 6 p.m. ET, when the action moves over to ESPN2. ESPN2 will air the U.S Open until 11 p.m. ET, and the entire tournament can be seen online with WatchESPN.

Among the players that will kick off the tournament this morning are David Goffin, Grigor Dimitrov, and Kei Nishikori, who is expected to advance far in the tournament. Djokovic isn’t scheduled to take the court until 3 pm. ET when he faces Joao Souza.

Rafael Nadal is set to play at night, taking on Borna Coric at 9 p.m. ET. The start times for the first matches for Andy Murray and Roger Federer have yet to be determined.

It’s been 12 years since an American last won the U.S. Open, and the streak is likely to continue. No.13 John Isner has the best chance to be the first U.S.-born player to win the event since Andy Roddick did it.

On the women's side, Serena Williams is a heavy favorite. The 33-year-old American is seeking her fourth consecutive U.S. Open title and 22nd overall. Williams will not face No. 3-ranked Maria Sharapova, who announced on Sunday that she won't compete in New York due to a leg injury.

Victoria Azarenka of Belarus is considered Williams' top competition. The 26-year-old has won two Australian Open titles, and reached the finals of the U.S. Open in 2012 and 2013.