Louisville Football
According to the Week 4 college football betting odds, Louisville is the biggest favorite of all the Top 25 ranked teams. Pictured: Khane Pass of the Louisville Cardinals celebrates with Zykiesis Cannon after a tackle for loss against the Clemson Tigers in the first quarter of a game at Papa John's Cardinal Stadium on Sept 16, 2017 in Louisville. Getty Images

Week 4 of the 2017 college football season has a chance to feature a few big losses by teams ranked in the AP Top 25 Poll. More than half of the ranked teams are on the road.

According to the latest betting odds, 11 teams are favored away from their home field. That includes No.1 Alabama, No.3 Oklahoma, No.4 Penn State and No.5 USC, all of whom are favored by double-digits. The betting lines in Saturday’s games range from 1.5 points to 44 points.

The 44-point spread comes in the game between Kent State and No.19 Louisville. The Cardinals are the biggest favorites among ranked teams, despite getting blown out by Clemson a week ago.

Oklahoma is the week’s biggest road favorite. They are coming off what was probably the most impressive win of the young season, winning by 15 points at Ohio State. The Buckeyes dropped to No.10 in the rankings with the loss, though they are 40-point home favorites against UNLV Saturday afternoon.

Two conference matchups include two ranked teams. No.16 TCU is getting nearly two touchdowns in their visit to No.6 Oklahoma. No.17 Mississippi State is a five-point underdog against No.11 Georgia.

No.20 Florida is barely favored in their SEC matchup Saturday night. The Gators are laying 1.5 points against Kentucky.

The late Saturday night game between No.24 Oregon and Arizona State will likely be a shootout. The over/under of 75 is the highest on the upcoming schedule.

Friday night’s only game could very well include a loss by a ranked team. No.23 Utah is favored by just 3.5 points for their visit to Arizona.

Below are the complete betting lines for all the Week 4 college football games with top-25 teams, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

No.23 Utah (-3.5) at Arizona, 56.5

UNLV (+40) at No.10 Ohio State, 65

NC State (+12.5) at No.12 Florida State, 51

Kent State (+44) at No.19 Louisville, 55.5

Old Dominion (+28) at No.13 Virginia Tech, 52.5

No.1 Alabama (-18.5) at Vanderbilt, 43

Boston College (-34) at No.2 Clemson, 53

No.5 USC (-17.5) at California, 64

No.16 TCU (+12.5) at No.6 Oklahoma State, 71.5

Toledo (+13) at No.14 Miami, 61

No.8 Michigan (-10) at Purdue, 51.5

Nevada (+28) at No.18 Washington State, 67.5

No.3 Oklahoma (-27.5) at Baylor, 62.5

No.17 Mississippi State (+5) at No.11 Georgia, 48.5

No.22 San Diego State (-3) at Air Force, 47.5

Syracuse (+21) at No.25 LSU, 57

No.4 Penn State (-12.5) at Iowa, 52

No.15 Auburn (-17.5) at Missouri, 60

No.20 Florida (-1.5) at Kentucky, 44

No.7 Washington (-11.5) at Colorado, 50

No.24 Oregon (-14.5) at Arizona State, 75.5