Clemson Kelly Bryant
The week 5 college football odds favor Clemson over Virginia Tech. Pictured: Kelly Bryant attempts a pass against the Boston College Eagles at Memorial Stadium on Sept. 23, 2017 in Clemson, South Carolina. Getty Images

Sixteen teams enter Week 5 of the 2017 college football season with an undefeated record and ranked in the AP Top 25 Poll. All but four of them are on the upcoming schedule, and at least one of those teams is guaranteed to suffer their first loss.

The betting odds favor every ranked team that isn’t facing another team in the top 25. The likes of No.1 Alabama, No.4 Penn State and No.11 Ohio State are expected to win without much trouble. While some of the betting lines are well north of 20 points, a few unbeaten teams are only favored by single digits.

It wouldn’t be surprising to see two playoff contenders suffer their first losses of the season Friday night. Having played just two games this year, No.14 Miami is laying less than a touchdown in their visit to Duke. No.5 USC is a five-point road favorite against Washington State in one of the year’s biggest Pac-12 matchups.

The biggest game of the weekend is scheduled for Saturday night between No.12 Virginia Tech and No.2 Clemson. The 4-0 Hokies are seven-point home underdogs against the defending national champions.

No.17 Louisville is the biggest favorite on the schedule, giving nearly 50 points to Murray State. Rutgers is nearly a 30-point underdog at home against Ohio State. Alabama is a 27-point home favorite over rival Ole Miss, coming off a 59-0 victory at Vanderbilt.

No.21 Florida is only a nine-point home favorite against Vanderbilt. The Gators are 2-1 on the season, having lost their first game of the year by 16 points to Michigan.

The Wolverines are off this weekend, as is No.3 Oklahoma, No.9 TCU, No.20 Utah and No.23 West Virginia. The Mountaineers are the only one of those teams that has suffered a loss this season.

Below are the complete betting lines for all the Week 5 college football games with top-25 teams, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

No.14 Miami (-6.5) at Duke, 55.5

No.5 USC (-5) at No.16 Washington State, 61.5

Northwestern (+14.5) at No.10 Wisconsin, 48

No.18 South Florida (-21.5) at East Carolina, 75.5

Vanderbilt (+9) at No.21 Florida, 41.5

Indiana (+17.5) at No.4 Penn State, 62

No.7 Georgia (-7) at Tennessee, 47

Murray State (+48.5) at No.17 Louisville, 63.5

Miami (Ohio) (+21) at No.22 Notre Dame, 53

No.24 Mississippi State (+9) at No.13 Auburn, 51

Troy (+20.5) at No.25 LSU, 49

No.11 Ohio State (-28.5) at Rutgers, 52.5

No.2 Clemson (-7) at No.12 Virginia Tech, 50.5

No.6 Washington (-26.5) at Oregon State, 60

No.15 Oklahoma State (-10.5) at Texas Tech, 84.5

Ole Miss (+27) at No.1 Alabama, 58

Northern Illinois (+10.5) at No.19 San Diego State, 49