Week 2 of the 2022 college football season is highlighted by a future SEC matchup. No. 1 Alabama visits unranked Texas, kickstarting a rivalry that will be born from upcoming conference expansion.

Texas has designs of regaining its position as one of the nation's top programs when it joins the best conference in the country. The Longhorns are set to officially leave the Big 12 for the SEC no later than 2025.

Alabama has dominated the SEC (and college football) during Nick Saban's tenure as head coach. With the impending expansion of the College Football Playoffs and postseason berths going to the top conference champions, Texas' decision to leave the Big 12 could initially hurt its national title aspirations.

Here are odds and predictions against the spread for the biggest games on the Week 2 schedule. Betting lines come from BetMGM.

No. 1 Alabama (-20.5) at Texas

Georgia might be the only team that can compete with Alabama this season. The Longhorns don't have what it takes to slow down Bryce Young and the Crimson Tide offense. Texas is in for a rude awakening after beating up on UL Monroe in Week 1.

Prediction ATS: Alabama

South Carolina (+7.5) at No. 16 Arkansas

Arkansas was impressive in a 31-24 win over Cincinnati, bolstered by KJ Jefferson's four touchdowns. The Razorbacks should take care of business at home against an unranked opponent.

Prediction ATS: Arkansas

No. 23 Wake Forest (-13) at Vanderbilt

When Vanderbilt is getting a lot of points at home, it's for a good reason. The Commodores are 5-15 against the spread as home underdogs since 2017.

Prediction ATS: Wake Forest

No. 24 Tennessee (-6) at No. 17 Pittsburgh

Even though Pittsburgh wasn't particularly impressive in its win over West Virginia, Tennessee won't have an easy time winning on the road by a touchdown. Quarterback Kedon Slovis made some big throws in his first start for the Panthers.

Prediction ATS: Pittsburgh

No. 25 Houston (+3.5) at Texas Tech

Houston played with fire and barely escaped with a victory over UTSA. The Cougars could be in trouble against a Texas Tech team that scored 63 points in the opener.

Prediction ATS: Texas Tech

No. 20 Kentucky (+6) at No. 12 Florida

Florida might have a Heisman Trophy candidate in Anthony Richardson. The quarterback Completed 70.8% of his passes, ran for 106 yards and scored three touchdowns in an upset win over Utah.

Prediction ATS: Florida

No. 10 USC (-8.5) at Stanford

The Trojans have the makings of a College Football Playoff team. Caleb Williams is in for a big season under Lincoln Riley.

Prediction ATS: USC

Arizona State (+11.5) at No. 11 Oklahoma State

On their way to making last year's Big 12 Championship Game, Oklahoma State won all three of its non-conference by a combined 13 points. Saturday could be another close win for the Cowboys.

Prediction ATS: Oklahoma State

No. 9 Baylor (+3) at No. 21 BYU

Baylor picked up where it left off last season, defeating Albany 69-10. The defending Big 12 champions can upset BYU on the road.

Prediction ATS: Baylor

Alabama Ohio State Football
(L-R) Head coach Urban Meyer of the Ohio State Buckeyes shakes hands with head coach Nick Saban of the Alabama Crimson Tide prior to the All-State Sugar Bowl at the Mercedes-Benz Superdome on January 1, 2015 in New Orleans, Louisiana. Streeter Lecka/Getty Images