The Dallas Cowboys and Seattle Seahawks are both good bets in highly anticipated Week 10 primetime games. The Buffalo Bills, Detroit Lions and Arizona Cardinals are live underdogs on the road. 

There’s no such thing as a “sure thing” when it comes to gambling, but here are the five best bets against the spread for Week 10 of the 2019 NFL season. These are the betting odds from the Westgate Las Vegas Super Contest.

Buffalo Bills (+3)

The Cleveland Browns have been the NFL’s most disappointing team in 2019 with six losses in eight games. Somehow they are favored over a Bills’ team that has six wins in eight games.

Buffalo currently has a wild-card berth because they’ve beaten up on bad teams, defeating the Jets, Giants, Bengals, Dolphins and Redskins. It’s clear that the Browns are a bad team as they continue to find ways to lose. Cleveland leads the league in penalties. They aren’t very good on either side of the ball, ranking 18th in total defense and 19th in total offense. The Bills are third in opponents’ yards per play. Baker Mayfield has thrown a league-high 12 interceptions. The Browns have scored fewer than 20 points in five of their losses.

Detroit Lions (+2.5)

The Chicago Bears are in the middle of a free fall and the Lions will be the beneficiaries in Week 10. Detroit can win in Soldier Field, where the Bears have been defeated twice in the last three weeks.

The Lions are probably the NFL’s best team that has a losing record. Detroit is undefeated in three games against sub-.500 teams and nearly upset a couple of first-place teams. Matthew Stafford is the biggest reason, posting a career-high 106.0 passer rating. The Lions are 31st in total defense and have given up an average of 32.5 points in their four losses, but the Bears could struggle against any defense at this point. Mitchell Trubisky should not be an NFL starting quarterback. The Bears are last in the NFC in yards per play.

Arizona Cardinals (+4.5)

Arizona’s 3-5-1 record is largely the result of a difficult schedule. The Cardinals are just as good as the Tampa Bay Buccaneers, making Arizona an easy pick as an underdog in their matchup with the 2-6 Bucs.

The Cardinals have been defeated by three first-place teams, the 7-2 Seahawks and the 5-3 Panthers. Arizona is undefeated in four games against some of the NFL’s worst defenses. Tampa Bay doesn’t exactly have an elite defense, ranking 23rd in yards allowed. The Buccaneers have given up at least 27 points in six straight games. The Cardinals just scored 25 points against the 49ers’ No.1 ranked defense. Kyler Murray has gone five straight games without throwing an interception.

Dallas Cowboys (-3)

The Cowboys appear to be back on track with two straight wins by a combined 46 points. Dallas should take care of business at home against the Minnesota Vikings Sunday night. 

Minnesota is coming off a loss in Kansas City, continuing to prove that they aren’t the same team on the road. Since the start of the 2018 season, Kirk Cousins and the Vikings are 1-6 against teams that have a record above .500, failing to cover the spread in each loss. Dallas is 5-1 with Tyron Smith at left tackle, only losing in New Orleans. The offensive line is healthy in Week 10. The Cowboys lead the NFL in total offense and yards per play. Dallas has scored more than 30 points in all five victories. 

Seattle Seahawks (+6.5)

Russell Wilson isn’t going to let the Seahawks get blown out in a game Seattle must win in order to stay in the NFC West race. Expect the “Monday Night Football” matchup between the Seahawks and San Francisco 49ers to go down to the wire.

Wilson was the clear MVP for the first half of the season. He leads the NFL with a 118.2 passer rating, 25 total touchdowns and just one interception. It hasn’t mattered that Seattle’s defense has been among the league’s worst because Wilson is consistently great, posting a passer rating north of 130.0 five times. As good as San Francisco’s defense is, the 49ers haven’t faced an elite quarterback. The Seahawks are fourth in total offense with the recipe to pull off the upset on the road. 

Season Record: 18-25-2

Russell Wilson Seattle Seahawks Quarterback Russell Wilson #3 of the Seattle Seahawks rushes against the Atlanta Falcons during the game at CenturyLink Field on Nov. 20, 2017 in Seattle. Photo: Otto Greule Jr /Getty Images