There are four straight days of football in NFL Week 16, starting with a Christmas Day matchup and concluding with the final “Monday Night Football” game of the year. Half of the schedule features a point spread of at least a touchdown.

Here are picks against the spread for every game in Week 16 of the 2020 NFL season, as well as the latest odds.

Betting lines and trends are courtesy of OddsShark.

Minnesota Vikings (+7) at New Orleans Saints

Drew Brees still hasn’t fully recovered from his 11 broken ribs, as evidenced by completing fewer than half of his passes in his return. An improving Minnesota secondary could at least keep the Vikings in this game and give Kirk Cousins a chance to make something happen in the fourth quarter.

Prediction ATS: Minnesota

Tampa Bay Buccaneers (-9.5) at Detroit Lions

Tom Brady should have one of his best games of 2020 against an awful Detroit pass defense. The Lions are surrendering a 107.0 passer rating to opposing quarterbacks. Every Detroit opponent in the last four weeks has scored more than 30 points.

Prediction ATS: Tampa Bay

San Francisco 49ers (+5) at Arizona Cardinals

The Cardinals should probably be favored by close to a touchdown Saturday. The 49ers have nothing to play for, eliminated from playoff contention with six losses in their last seven games. Kyler Murray appears to be out of his funk, winning the NFC Player of the Week award. San Francisco is 0-5-1 against the spread in its last six games against Arizona.

Prediction ATS: Arizona

Miami Dolphins (-3) at Las Vegas Raiders

Las Vegas’ offense kept rolling right along in Week 15 when Marcus Mariota replaced the injured Derek Carr under center. Miami will have to score in order to beat the Raiders, and the Dolphins have scored fewer than 23 points in four of their last five games.

Prediction ATS: Las Vegas

Cleveland Browns (-9.5) at New York Jets

The Jets picked up their one victory for the season. Now it’s time for New York to go back to its losing ways. The Browns just took care of the Giants 20-6 at MetLife Stadium, and Sunday’s contest could be very similar.

Prediction ATS: Cleveland

Atlanta Falcons (+10.5) at Kansas City Chiefs

Even though they keep beating teams, the Chiefs barely managed to end their five-game losing streak against the spread in Week 15. Raheem Morris has Atlanta playing hard and the defense being competitive. In nine games since Dan Quinn was fired, the Falcons have only lost one game by more than five points.

Prediction ATS: Atlanta

Cincinnati Bengals (+9) at Houston Texans

This line is probably too high, considering what little Houston has around Deshaun Watson. Cincinnati has been competitive defensively, allowing 20 points or fewer in four of its last five games. The Texans only have one win by more than seven points in their last nine games.

Prediction ATS: Cincinnati

Indianapolis Colts (-1.5) at Pittsburgh Steelers

How can you pick the Steelers to beat a good team right now? Pittsburgh appears to be in a free fall with three straight losses, two of which have come against losing teams. Indianapolis’ defense isn’t what it was to start the season, but it’ll play well against a Pittsburgh offense that can’t run the ball and ranks 27th in yards per play.

Prediction ATS: Indianapolis

New York Giants (+11) at Baltimore Ravens

Even in largely one-sided defeats, New York’s defense has played well enough to give the Giants a chance. The Giants have given up an average of 19.8 points over the last nine games, holding every single opponent below 27 points. That could be enough to keep the Giants within 10 points Sunday.

Prediction ATS: New York

Chicago Bears (-7.5) at Jacksonville Jaguars

The Jaguars were handed a gift last week when they took control of the No.1 draft pick, and they won’t give it back. Chicago’s offense is playing well enough to win this game comfortably. Jacksonville is 4-8 against the spread in its last 12 games.

Prediction ATS: Chicago

Denver Broncos (+3) at Los Angeles Chargers

It’s hard to ever feel comfortable betting the Chargers as favorites, considering how much of a disaster they have been in late and close situations. Denver beat Los Angeles 31-30 earlier this season. The Broncos are 4-1 against the spread in their last five games against the Chargers.

Prediction ATS: Denver

Carolina Panthers (+2.5) at Washington Football Team

Washington has a bit of a mess on its hands at quarterback with Alex Smith’s injury and Dwayne Haskins’ latest transgression. The Panthers are perfect against the spread in their last six games as road underdogs.

Prediction ATS: Carolina

Los Angeles Rams (+1.5) at Seattle Seahawks

With Jalen Ramsey leading the secondary, the Rams are 2-0 against the Seahawks and allowing just 14 points per game. Russell Wilson has been held in check lately when facing above-average defenses, and the Rams still rank first in opponents’ yards per play. Seattle’s improvement on defense over the last month has a lot to do with a weak schedule.

Prediction ATS: Los Angeles

Philadelphia Eagles (-2.5) at Dallas Cowboys

Jalen Hurts might have turned the Eagles back into the best team in the NFC East. The quarterback has accounted for 674 total yards and five touchdowns in his two starts against a pair of good teams. Don’t get too excited over Dallas' two-game winning streak against Brandon Allen and Nick Mullens.

Prediction ATS: Philadelphia

Tennessee Titans (+3.5) at Green Bay Packers

A matchup between two of the NFL’s top-three offenses, this is the best game on the Week 16 schedule. Neither team plays much defense, and the last quarterback with the ball might win. Look for Ryan Tannehill and Aaron Rodgers to put up big numbers in a close contest.

Prediction ATS: Tennessee

Buffalo Bills (-7) at New England Patriots

Buffalo is the second-best team in the AFC and possibly the entire NFL. The Patriots are out of contention. If New England falls behind, they won’t be able to mount a comeback. Cam Newton has twice as many interceptions as passing touchdowns. Bill Belichick could decide to give Jarrett Stidham some snaps if Buffalo leads in the second half.

Prediction ATS: Buffalo

Jalen Hurts Philadelphia Eagles
Jalen Hurts #2 of the Philadelphia Eagles throws the ball during a game against the Arizona Cardinals at State Farm Stadium on December 20, 2020 in Glendale, Arizona. Norm Hall/Getty Images