Pope Francis warned world leaders on Friday against a growing breakdown of multilateralism, appealing in a speech to the United Nations for an end to what he called a global "climate of distrust."

"At present we are witnessing an erosion of multilateralism, which is all the more serious in light of the development of new forms of military technology," the Argentine pope said in a video address to the UN General Assembly in New York.

"We need to break with the present climate of distrust," said the pontiff, who called for relaxing international sanctions as harmful to civilian populations, without citing specific countries.

Francis' sharply worded rebuke to the UN did not call out any one nation or leader.

But the spiritual head of 1.3 billion Catholics worldwide reproached the international community for what he characterized as a lax and disjointed response to a host of pressing social issues, including human rights, refugees and humanitarian crises, destruction of the environment, economic inequality and nuclear proliferation.

He contrasted his comments before the body to his last address in person in 2015, a time "marked by truly dynamic multilateralism," he said.

"It was a moment of great hope and promise for the international community," coming just ahead of the adoption of the UN's 2030 Agenda for Sustainable Development, a pledge to end poverty and hunger, and the subsequent adoption of the Paris climate accord to fight climate change.

"We must honestly admit that, even though some progress has been made, the international community has shown itself largely incapable of honoring the promises made five years ago," Francis said.

Pope Francis delivered a video address to the United Nations General Assembly in New York
Pope Francis delivered a video address to the United Nations General Assembly in New York AFP / Filippo MONTEFORTE

President Donald Trump has pulled the United States out of the Paris climate agreement, whose future will be partly determined by the outcome of the November 3 US election -- with Trump's rival Joe Biden pledging to return to the accords.

Francis, who has made defense of the poor and of the environment a central theme of his papacy, said the world faced a choice between "multilateralism as the expression of a renewed sense of global co-responsibility" or, on the other hand, a path towards nationalism, protectionism and isolation.

"It excludes the poor, the vulnerable, and those dwelling on the peripheries of life," Francis said, warning that such a path would be "detrimental to the whole community."

"We must also admit that humanitarian crises have become the status quo," he added, saying that efforts to tackle such global crises, often failed because "individual states shirk their responsibilities and commitments."

The pope also made a lengthy appeal for nuclear disarmament, and against militarization in all its forms.

"We need to dismantle the perverse logic that links personal and national security to the possession of weaponry," said the pope, charging that military spending "continues to squander precious resources that could better be used to benefit the integral development of peoples and protect the natural environment."