A passerby wearing a protective face mask walks past an electric screen displaying a graph showing Japan's Nikkei share average, amid the coronavirus disease (COVID-19) pandemic, in Tokyo, Japan February 24, 2022.
A passerby wearing a protective face mask walks past an electric screen displaying a graph showing Japan's Nikkei share average, amid the coronavirus disease (COVID-19) pandemic, in Tokyo, Japan February 24, 2022. Reuters / ISSEI KATO

A rebound in stocks ran out of steam on Wednesday as concerns about the economic growth outlook and rising inflation knocked sentiment, while a UK inflation reading of 9% underlined just how much higher interest rates might be headed.

European shares were mostly lower and futures on Wall Street pointed to a weaker open.

Many analysts have characterised this week's sharp rally as a short-term bounce of the sort common during a lengthier downward trend for equities. Few are willing to predict the end to selling after a bruising first five months of the year for risky assets given so much macroeconomic uncertainty.

"Investor sentiment and confidence remain shaky, and as a result, we are likely to see volatile and choppy markets until we get further clarity on the 3Rs -- rates, recession, and risk," said Mark Haefele, chief investment officer at UBS Global Wealth Management.

By 1115 GMT, the broad Euro STOXX 600 was off 0.35%, while Britain's FTSE 100 was 0.23% lower.

MSCI's broadest index of Asia-Pacific shares outside Japan rose 0.68% and is on its longest winning streak since February. Japan's Nikkei rose 0.94% and miners led Australian shares about 1% higher. [.T][.AX]

The MSCI World Equity Index inched up 0.1% and is nearly 2% higher so far this week, but remains down 16% from its peak in January.

In currency markets, sterling was the big loser, shedding as much as 1% to $1.2373 after UK consumer price inflation hit 9% in April, a 40-year high and roughly in line with analysts' expectations. The pound had risen sharply this week and some of Wednesday's fall was down to profit taking.

British inflation is now the highest among major economies but prices are rising rapidly across the world, forcing central banks to hike rates even in the face of slowing economic growth momentum.

Canada's April inflation reading is also due later on Wednesday.

The U.S. dollar rose 0.3% to 103.62 after a big fall on Thursday and headed back towards its two-decade high reached last week, while the euro fell by a similar amount to $1.0513.

NEGATIVE SHOCKS

Positive data has helped the mood this week, with U.S. retail sales meeting forecasts for a solid increase in April and industrial production beating expectations.

Data on Wednesday showed Japan's economy shrank less than expected in the first quarter.

Shanghai is edging towards an end to its protracted lockdown and China's vice-premier made soothing comments to tech executives in the latest sign of a let up in pressure.

However, good news was offset by the reminder from Federal Reserve Chair Jerome Powell that controlling inflation would demand rate rises and possibly some pain.

Investors have priced in 50 basis point U.S. rate hikes in June and July and see the benchmark Fed funds rate nudging 3% by early next year.

U.S. Treasury yields were steady on Wednesday below recent multi-year highs, but the German 2-year government bond yield shot to its highest since December 2011 after more hawkish central banker comments. The European Central Bank's Klaas Knot said on Tuesday that a 50 basis point rate hike in July was possible if inflation broadens.

Commodities have rallied with stocks this week, although most prices are below recent highs.

On Wednesday Brent crude futures gained 0.85% to $112.88 a barrel and U.S. crude futures rose 1.19% to $113.74 a barrel.

S&P Global Ratings cut growth forecasts for China, the United States and the euro zone, underlining the weakening outlook for the world's major economies.

"Two developments have altered the macro picture," said chief economist Paul F. Gruenwald, pointing to Russia's invasion of Ukraine and inflation, which has turned out to be higher, broader and more persistent than first thought.