Having won the main event of the biggest UFC pay-per-view of all time less than three months ago, Conor McGregor is expected to do the same thing on Saturday night. The Irish fighter is favored in his lightweight championship bout with Eddie Alvarez at UFC 205 at Madison Square Garden.

McGregor is the biggest draw in MMA history, and his win over Nate Diaz at UFC 202 on Aug. 20 helped set a record with a reported 1.65 million pay-per-view buys. Even more people are expected to witness McGregor’s quest to become the first fighter ever to hold two UFC belts at the same time.

McGregor is undefeated in UFC at 145 pounds, holding the featherweight title. He’s 1-1 at 170 pounds, having lost to Diaz at that weight at UFC 196 in March. Saturday marks McGregor first-ever UFC fight at 155 pounds, but he remains the favorite with -165 betting odds to defeat the current champion.

Alvarez presents a difficult challenge for McGregor. He’s won three fights in a row, including a first-round knockout of former champion Rafael dos Anjos on July 7. Alvarez is just a +135 underdog against McGregor, via Bovada.lv, making for one of several fights on the UFC 205 main card that will be difficult to predict.

Of the six fights on the PPV, all but one underdog has better than 2/1 odds. Chris Weidman (-175) takes on Yoel Romero (+145) in a fight that could determine the No. 1 contender for the middleweight title, and Donald Cerrone (-160) is favored against Kelvin Gastelum in a welterweight fight.

Tyron Woodley is less than four months removed from defeating Robbie Lawler for the welterweight title, but he might not be the champ for much longer. He’s a +165 underdog against Stephen Thompson, who is the second-biggest favorite on the card with -205 odds.

Only Joanna Jedrzejczyk is a bigger favorite on the PPV. The women’s strawweight champion has -400 odds to defeat Karolina Kowalkiewicz, who is a +300 underdog.

Rounding out the PPV is the women’s bantamweight fight between Miesha Tate (-175) and Raquel Pennington (+145). Tate hasn’t fought since her loss at UFC 202, which prevented the former champ from getting a rematch with Ronda Rousey.