When and Where: The Europa League last-16 second leg kicks off from San Mames at 2 p.m. ET. The match is being screened on GOLTV. If you're in the U.K., you can watch a live stream at Channel5.com.

Preview: Despite trailing 3-2 going into this second-leg of their Europa League last-16 tie, Manchester United know they could be in an even worse position after being thoroughly outplayed against Athletic Bilbao at Old Trafford.

While they may have gone top of the Premier League at the weekend, it has been a different story for United in Europe this season. Several disastrous Champions League performances saw them exit at the group stage, while they only narrowly scraped past Ajax in the last round of the Europa League.

A drastic improvement will be needed if Sir Alex Ferguson's men are to have any chance of getting a desired result in Spain on Thursday.

Bilbao, meanwhile, will have had their confidence boosted by the ease at which they got at United three weeks ago.

While their recent good form was interrupted somewhat with a defeat to Osasuna at the weekend, key men Fernando Llorente and Javi Martinez were left out of the lineup in anticipation for Thursday's clash.

Team News: Bilbao will be strengthened for the second-leg by the return of defender Fernando Amorebieta from suspension. The Venezuelan's presence will also allow Javi Martinez to slot into his best position in midfield.

With Chris Smalling only fit enough for a place on the bench and Phil Jones stricken with flu, Ferguson has revealed that Rio Ferdinand will partner Jonny Evans at the heart of the United defense.

Meanwhile, Brazilian midfielder Anderson has suffered a hamstring injury and will be out for at least a month. Although Nani could also be missing for the game, United could be boosted by the return of fellow-winger Antonio Valencia.

Prediction: Many mangers would be tempted to set out their side to defend such a positive result away from home in the first-leg, but there is little chance of Marcelo Bielsa adopting this approach. The always offense-minded Argentinian will surely look to unleash the likes of Llorente and Iker Munian to try and expose United defensively once more.

Coupled with the Red Devils' need to score at least twice, there is a strong prospect of another high-scoring affair. But regardless of their opponent's openness, it's difficult to see United attaining the necessary scoreline to advance.

Athletic Bilbao 2-2 Manchester United