Nineteen games that feature at least one team ranked in the AP Top 25 Poll are scheduled for Saturday in Week 5 of the 2016 college football season. A few of the nation’s best teams will face weak opponents, but some national title contenders have a real chance to suffer their first losses of the year.

The biggest game on the schedule is set for Saturday night in Clemson. The No.5 team in the country is a home underdog against No.3 Louisville. The Cardinals have looked unbeatable this season, and quarterback Lamar Jackson is the favorite to win the Heisman Trophy. He has 13 passing touchdowns and 12 rushing touchdowns, scoring more times than most teams in 2016.

No.11 Tennessee is a small favorite for their visit to No.25 Georgia. The Bulldogs are coming off a 31-point loss against Ole Miss, and their last five games against Tennessee have all been decided by one score.

No.20 Arkansas has the easiest task of any ranked team that plays on Saturday. The Razorbacks host Alcorn State of the FCS, and oddsmakers haven’t even set betting odds for the contest.

Six of the games that include a ranked team feature a betting line of less than seven points, via OddsShark. Notre Dame is no longer ranked, but they are 10-point favorites in their visit to Syracuse.

Lamar Jackson Louisville Lamar Jackson passes the ball during a game against Florida State at Papa John's Cardinal Stadium on Sept. 17, 2016 in Louisville, Kentucky. Photo: Getty

Betting Odds & TV Info

Notre Dame (-10) at Syracuse, 73: ESPN, noon EDT

No.13 Baylor (-16.5) at Iowa State, 61: FS1, noon EDT

No.23 Florida (-10) at Vanderbilt, 40.5: SEC Network, noon EDT

No.22 Texas (+2.5) at Oklahoma State, 70: ABC, noon EDT

Rutgers (+38.5) at No.2 Ohio State, 60: Big Ten Network, noon EDT

No.14 Miami (-7.5) at Georgia Tech, 53: ESPN 2, noon EDT

No.11 Tennessee (-3.5) at No.25 Georgia, 52.5: CBS, 3:30 p.m. EDT

North Carolina (+10.5) at No.12 Florida State, 70.5: ESPN, 3:30 p.m. EDT

No.8 Wisconsin (+10.5) at No.4 Michigan, 44.5: ABC, 3:30 p.m. EDT

Illinois (+20.5) at No.15 Nebraska, 53: ESPN 2, 3:30 p.m. EDT

No.9 Texas A&M (-17.5) at South Carolina, 48: SEC Network 4 p.m. EDT

Oklahoma (-3.5) at No.21 TCU, 69.5: FOX, 5 p.m. EDT

No.18 Utah (+2) at California, 65: Pac-12 Network, 6 p.m. EDT

Memphis (+14.5) at No.16 Ole Miss, 69: ESPN 2, 7 p.m. EDT

Kentucky (+35.5) at No.1 Alabama, 57.5: ESPN, 7 p.m. EDT

No.3 Louisville (-2) at No.5 Clemson, 67.5: ABC, 8 p.m. EDT

No.19 San Diego State (-19) at South Alabama, 51: ESPN News, 8 p.m. EDT

No.17 Michigan State (-6.5) at Indiana, 52.5: Big Ten Network, 8 p.m. EDT

Utah State (+21.5) at No.24 Boise State, 59: ESPN 2, 10:15 p.m. EDT