The Conrad Murray trial began early Monday morning at the Los Angeles criminal courthouse.
The physician arrived with his mother just moments before members of Michael Jackson's family, including parents Katherine and Joe and sisters Janet and La Toya, pulled up to the courthouse, which was populated by police escorts, fans and news vans.
Murray, 58, is on trial on charges of involuntary manslaughter in the 2009 death of Jackson.
The trial began with Deputy District Attorney David Walgren showing an eerie photo of the late King of Pop lying on a gurney with his mouth open and eyes closed.
Prosecution then played a haunting audio recording of Jackson describing his This Is It comeback tour to Murray. The recording was made on Murray's phone just over a month before Jackson's death.
We have to be phenomenal . . . when people leave this show, when people leave my show, I want them to say I've never seen nothing like this in my life. Go. Go. I've never seen nothing like this. Go. It's amazing. He's the greatest entertainer in the world, Jackson mumbled in the recording.
In the courtroom, La Toya Jackson was seen carrying a sunflower as her family looked on, CBS News reports.
On June 25, 2009, Jackson died at the age of 50 from an overdose of the anesthetic propofol, which the singer frequently depended on to sleep.
If convicted, Murray could face four years in prison along with the loss of his medical license.
Jackson, who earned an estimated $1 billion they ear following his death, remains the most successful artist of all time.