With Donald Trump and Hillary Clinton's big wins in Tuesday's primaries, the candidates and the media are starting to look ahead to the general election. For late-night comedians, that means it's time for some jokes about the candidates' possible running mates. 

On Tuesday's episode of NBC's "Late Night with Seth Meyers," host Meyers used his "Closer Look" segment to examine the options available to the candidates to fill out their general election tickets, while also mocking the media's rush to speculate.

Meyers started with Clinton and Ohio Gov. John Kasich. Clinton says she has not begun to think about who she would choose to be her vice presidential nominee, but the Kasich campaign told the press it has already started vetting candidates, despite his low delegate count and lack of a path to the nomination.

"John Kasich picking a running mate is like Vin Diesel practicing his Academy Award acceptance speech," joked Meyers. 

Moving on to Donald Trump, Meyers hypothesized that the businessman might choose to balance out his ticket with a complementary candidate, the way a young, black Barack Obama picked the older, white Joe Biden to be his running mate. 

"If Donald Trump goes for the opposite technique, the question is who is the opposite of Donald Trump?" Meyers asked. "Is it a Mexican guy who tears down walls with his giant hands?"

Finally, Meyers returned to Clinton to address the idea that she should pick her current opponent, Vermont Sen. Bernie Sanders, or Massachusetts Sen. Elizabeth Warren, to preserve the progressive vote. Meyers mocked the idea that a ticket with two women would be inherently unsuccessful. 

"Some might say, 'Is it feasible to have a woman as president and vice president in the same country that lost its collective mind over the all-female 'Ghostbusters'?'" Meyers chided. "You could never have two people of the same gender in the White House — except for the last 44 times."

Watch Seth Meyers break down the presidential candidates' running mate options in the clip from "Late Night" below:

On Tuesday, Clinton pulled farther ahead of Bernie Sanders with wins in the primaries in Connecticut, Delaware, Maryland and Pennsylvania — Sanders only won in Rhode Island. Meanwhile, Donald Trump strengthened his stranglehold over the GOP nomination with a sweep of all five of those states on the Republican side.