When and Where to Watch: You can watch the friendly game from Genoa, Italy online on ESPN3, via Watch ESPN. If you have access to a TV, it is also available on ESPN2.The match kicks-off at 2.45 p.m. ET.
Preview: U.S. coach Jurgen Klinsmann will be without key man Landon Donovan and several other regulars for the United States' trip to Genoa to face Italy on Wednesday.
Donovan pulled out on Sunday through illness, joining Jermaine Jones, José Torres and Timmy Chandler on the sidelines for what is an imposing test for Klinsmann's new regime.
The German took over from Bob Bradley last July and has overseen a mixed bag of results thus far. After a poor start that included defeats to Costa Rica, Belgium, Ecuador and France, things got back on track with a 3-2 win in Slovenia last November.
Though this is the first time that Klinsmann will be picking from his first-choice players since that match, injuries have hampered the World Cup winner's preparations. Klinsmann has still been unable to pick the U.S.'s two star names, Donovan and Clint Dempsey, in the same lineup since taking charge.
Whatever situation you face with injuries right before games, you just take it the way it is, Klinsmann said, according to Sports Illustrated.
If José Torres or Landon Donovan can't come in, you've got to solve it. The players that get the next opportunity are hungry. They want to steal the spot from the one that isn't there. This is the nature of the beast of soccer. We're going to have a very competitive side on Wednesday night.
FC Dallas' Brek Shea and Anderlecht's Sacha Kljestan have been called up as replacements.
While the U.S. can still afford to experiment a little, Italy manager Cesare Prandelli will be looking to move closer to knowing the squad that he will take to the European Championships in June.
Prandelli controversially left out striker Mario Balotelli, citing that the Manchester City players' disciplinary problems meant that he could not be trusted. Balotelli was sent off after kicking out at Tottenham's Scott Parker last month.
The players know it, acting like this they risk missing the Euros, Prandelli said, according to the Daily Telegraph.
Enough of this football full of rash reactions and punches, it is a sign of weakness. You can't be in the national squad if you risk leaving the team with 10 men.
Another victim of the Italy boss' stern policy is Roma's Pablo Osvaldo, who is currently suspended following a dismissal of his own. Osvaldo and Balotelli played up front together for Italy last time out in their 1-0 home defeat to Uruguay.
With Antonio Cassano and Giuseppe Rossi out injured and highly doubtful to be fit for this summer's tournament, it makes Prandelli's stance all the more principled. For Wednesday's game, Juventus' Alessandro Matri will lead the line alongside Parma's Sebastian Giovinco.
If those two are to thrive up front then it is likely that revitalized midfield schemer Andrea Pirlo will be the one to supply them with the ammunition. Alongside Pirlo, Milan's Antonio Nocerino is also a threat, having amassed an impressive goalscoring record this season.
Italy starting lineup (confirmed): Buffon; Maggio, Barzagli, Ogbonna, Cristico; Marchisio, Pirlo, Thiago Motta, Nocerino; Giovinco, Matri