Junior dos Santos defeated Cain Velasquez in Anaheim, Calif., Saturday night to capture the UFC heavyweight championship.

Velasquez's reign as heavyweight champion lasted 13 months, and it ended in the same Honda Center as it began.

With about 4:04 left in the first round, dos Santos threw a devastating punch with his right hand that landed and knocked a dazed Velasquez to the ground.

Dos Santos continued his assault with Velasquez on the ground, landing a flurry of punches to the head and face. At about the 3:56 mark of the first round, the referee called the match, a total knockout for dos Santos. It took just more than a minute for dos Santos to unseat Velasquez.

Dos Santos ran around the octagon with his hands up in celebration, and he finally stopped in the center and fell to the ground.

I have no words to say what I am feeling, dos Santos said in a postgame interview in the octagon on Fox. It's amazing, my life. I want to say thank you to my family. I have a lot of good people around me.

Both fighters came into the match undefeated in UFC competition. Dos Santos is now 8-0 in UFC, while Velasquez drops to 9-1.

The fight was also Velasquez's first since his title-winning fight last year in Anaheim. He defeated Brock Lesnar about 13 months ago in California, but he suffered a torn rotator cuff in his right shoulder and needed surgery.

He was surprised by the punch that started his downfall.

He messed up my equilibrium, Velasquez said. It was a good shot. He has a lot of power. I waited too much and he went in and did what he was supposed to do.

At weigh-ins on Friday, Velasquez was 249 pounds and dos Santos was 239 pounds, according to Fox Sports.

Dos Santos' will have an opportunity to defend his title against the winner of a Dec. 30 fight between Lesnar and Alistar Overeem.