The Twitterverse is exploding with reaction to deposed Tour de France winner Lance Armstrong coming clean about doping throughout his entire cycling career.

In an exclusive interview with Oprah Winfrey whose first half was broadcast Thursday on her OWN channel, the 41-year-old athlete admits to the queen of talk that he used performance-enhancement drugs.

For years Armstrong denied using any inorganic methods to help him win competitions, but in 2012 he was disqualified for using and distributing PED and banned from cycling for life after being investigated by the U.S. Anti-Doping Agency.

After stepping down as chairman from Livestrong, the foundation the cancer survivor started to help raise money for others with cancer, Armstrong soon agreed to do a tell-all interview with Winfrey.

The athlete took the world by storm with his supposed success story: Here was a man who overcame cancer to go on to achieve a bronze medal (now revoked) in the 2000 Olympics and take home seven consecutive Tour de France titles from 1995 to 2002.

Hundreds of tweets about Armstrong began to unfold Thursday evening as celebrities, actors and athletes alike weighed in on his interview.

New York Yankees first baseman Mark “Tex” Teixeira didn’t comment on the fallen athlete, but instead focused on the host of the show.

“Watching @Oprah and @lancearmstrong interview,” he said. “No matter the topic, Oprah is a darn good interviewer. Good TV.”

Actor and producer Tom Arnold agreed that as Armstrong tried to dodge some of Winfrey's tougher questions, she  continued to gingerly probe him to get the truth.

“A lot of sports journalists were questioning if Oprah had what it takes to thoroughly interview Lance Armstrong. The woman is shredding him.”

Simon Van Kempen, who recently appeared on VH1’s “Couples Therapy” and garnered fame appearing on “The Real Housewives of New York,” had troubled believing anything that the athlete said.

“The problem I have with @LanceArmstrong swearing he was clean in 2009 & 2010 is that It is so hard to believe someone who's lied for so long.”

Armstrong explained to the 58-year-old talk show host that he had portrayed his life to be “perfect,” and it was a difficult standard to live up to.

He referred to “the EPO [erythropoietin] culture” of the 1990s and implied that other athletes were doping while competing in the sport saying, “it was what it was” but wouldn’t give any names.

It was impossible to win the Tour de France without using illegal substances, he said. 

He referred to those who were riding clean as heroes, but went as far as saying that there were only four or five contestants who didn’t use PED.

But no matter what Armstrong said, British CNN host Piers Morgan couldn’t get around the fact that the cyclist had lied for years upon years.

“So it's official - @lancearmstrong is the worst lying, doping cheat in the history of sport. #LiveWrong.”

Australian journalist Mark Colvin had a series of tweets with similar views:

“Dear Oprah, There's no point asking a psychopath what he 'feels', no matter how many times you do it.”

The banned cyclist granted in the beginning of the Winfrey interview that comes confession is too late, many celebrities and athletes agree.

Though the athlete finally came clean after years of lying, his reputation will be presumably tarnished for life.