Dr. William Masters and Mrs. Virginia Johnson’s story has come to an end.

Showtime has canceled sexual drama “Masters Of Sex” after four seasons. The Season 4 finale, which aired on Sunday, Nov. 10, is now the series finale. It showed Bill (Michael Sheen) and Virginia (Lizzy Caplan) finally tying the knot and Bill’s wife Libby (Caitlin Fitzgerald) moving to California to pursue a career in law.

Deadline first reported that there will be no Season 5 of the series based on the real lives of human sexuality pioneers Masters and Johnson. Showtime said in a statement, “'Masters Of Sex’ was a beautifully written and acted exploration of America’s changing sexual mores. We are incredibly proud to have shared the story of Masters and Johnson for four critically-acclaimed seasons. The series will remain available across our platforms where new viewers can discover it for years to come.”

Although the show garnered significant critical acclaim, the ratings were not-so-good. Season 4 only averaged 800,000 viewers. Even when Showtime factored in the viewership across multiple platforms, it averaged only 2.16 million.

Most “Masters Of Sex” fans are angry and disappointed with Showtime’s decision. However, a few feel that the Season 4 finale was a fitting end to the complicated lives of Masters and Johnson. Still, many viewers have spoken about the lack of a conclusion to Betty’s (Annaleigh Ashford) storyline.

Fitzgerald reacted to the cancelation news on Instagram:

Here are some of the fan reactions to the cancellation of “Masters Of Sex” on Twitter below:

All episodes of “Masters Of Sex” are available for viewing on the Showtime website.

How do you feel about the ending of “Masters Of Sex”? Are you bummed it got canceled? Tweet your thoughts to @nemisha17 or hit the comments section below.